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Prepublished online as a Blood First Edition Paper on October 24, 2002; DOI 10.1182/blood-2002-09-2963. This Article Full Text (PDF) All Versions of this Article: 2002-09-2963v1 101/6/2335    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Streubel, B. Articles by Chott, A. Search for Related Content PubMed PubMed Citation Articles by Streubel, B. Articles by Chott, A. Social Bookmarking                   What's this? Submitted September 30, 2002 Accepted October 17, 2002 T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma Berthold Streubel, Andrea Lamprecht, Judith Dierlamm, Lorenzo Cerroni, Manfred Stolte, German Ott, Markus Raderer, and Andreas Chott* Department of Pathology, University of Vienna, Vienna, Austria Department of Hematology and Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Germany Department of Dermatology, University of Graz, Graz, Austria Department of Pathology, Klinikum Bayreuth, Bayreuth, Germany Department of Pathology, University of Wuerzburg, Wuerzburg, Germany Department of Oncology, University of Vienna, Vienna, Austria * Corresponding author; email: andreas.chott{at}akh-wien.ac.at. T(11;18)(q21;q21) is the most common structural abnormality in extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) leading to the fusion of the apoptosis inhibitor-2 (API2) gene and the MALT lymphoma-associated translocation (MALT1) gene. In two patients with MALT lymphoma of the liver and skin, respectively, t(14;18)(q32;q21) was observed by cytogenetic analysis. Subsequent fluorescence in situ hybridization (FISH) studies disclosed that the immunoglobulin heavy chain locus (IGH) and the MALT1 gene were rearranged by this translocation. In order to screen a large series of MALT lymphomas for this aberration, a two-color interphase FISH assay was established. Among a total of 66 cases t(14;18)(q32;q21) involving IGH and MALT1 was detected in MALT lymphomas of the liver (4/4), skin (3/11), ocular adnexa (3/8), and salivary gland (2/11), but did not occur in MALT lymphomas of the stomach (n=10), intestine (n=9), lung (n=7), thyroid (n=4), and breast (n=2). In total, 12 of 66 (18%) MALT lymphomas harbored t(14;18)(q32;q21), 7 additional cases of splenic marginal zone lymphoma were tested negative. All of the 12 MALT lymphomas featuring the t(14;18)(q32;q21) were negative for t(11;18)(q21;q21) by RT-PCR, however, trisomy 3 and/or 18 was found in 4/12 cases, suggesting that the t(14;18)(q32;q21) does not occur as the sole genetic abnormality. This study identifies IGH as a new translocation partner of MALT1 in MALT lymphomas, which tend to arise frequently at sites other than the gastrointestinal tract and lung. In contrast to t(11;18)(q21;21)+ MALT lymphomas, those with t(14;18)(q32;q21) may harbor additional genetic abnormalities. 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