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Prepublished online as a Blood First Edition Paper on March 27, 2003; DOI 10.1182/blood-2002-09-2966. This Article Full Text (PDF) All Versions of this Article: 2002-09-2966v1 102/2/585    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sun, C.-M. Articles by Lo-Man, R. Search for Related Content PubMed PubMed Citation Articles by Sun, C.-M. Articles by Lo-Man, R. Social Bookmarking                   What's this? Submitted October 15, 2002 Accepted March 18, 2003 Ontogeny and innate properties of neonatal dendritic cells Cheng-Ming Sun, Laurence Fiette, Myriam Tanguy, Claude Leclerc, and Richard Lo-Man* Biologie des Regulations Immunitaires, INSERM 0253, Institut Pasteur, Paris, France Recherche et Expertise en Histologie et Pathologie, Institut Pasteur, Paris, France * Corresponding author; email: RLOMAN{at}PASTEUR.FR. We investigated whether a developmental immaturity of the dendritic cells (DCs) compartment could contribute to the high susceptibility to infections observed in newborns. DCs are among the first cells to colonize the spleen, but the ontogeny of DC subsets follows distinct steps. At birth, plasmacytoid DCs and CD4- CD8- DCs are found in the spleen, whereas CD8+ or CD4+ DCs are not present. Then, the CD8+ DC compartment quickly develops and reach an adult size by day 7, whereas the CD4+ DC compartment slowly increases to become predominant by the age of 3 weeks. The production of IL-12p70 and type I and II interferons by DCs is particularly efficient after birth, reflecting the stronger capacity of the neonatal CD8- DCs to secrete IL-12 as compared to its adult counterpart. Likewise, neonatal DCs produced type I and II interferons. In vivo, following microbial stimulation, upregulation of MHC and of costimulatory molecules on DCs was induced clearly showing the activation of neonatal DCs in the neonatal environment. Therefore, despite a markedly different DC subset composition in early life as compared to the adult DC compartment, neonatal DCs are fully competent in their innate immune functions. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H.-H. Lee, C. M. Hoeman, J. C. Hardaway, F. B. Guloglu, J. S. Ellis, R. Jain, R. Divekar, D. M. Tartar, C. L. Haymaker, and H. 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