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Prepublished online as a Blood First Edition Paper on March 20, 2003; DOI 10.1182/blood-2002-10-3170. This Article Full Text (PDF) All Versions of this Article: 2002-10-3170v1 102/1/388    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by James, E. Articles by Simpson, E. Search for Related Content PubMed PubMed Citation Articles by James, E. Articles by Simpson, E. Social Bookmarking                   What's this? Submitted October 21, 2002 Accepted March 4, 2003 Multiparity induces priming to male-specific minor histocompatibility antigen, HY, in mice and humans Edward James, Jian-Guo Chai, Hamlata Dewchand, Eugenio Macchiarulo, Francesco Dazzi, and Elizabeth Simpson* Transplantation Biology Group, Clinical Sciences Centre, Imperial College Faculty of Medicine, London, United Kingdom Department of Immunology, Imperial College Faculty of Medicine, London, United Kingdom * Corresponding author; email: esimpson{at}ic.ac.uk. One of the factors which increases the risk of graft-versus-host disease following allogeneic stem cell transplantation is the use of multiparous females as donors. Since minor histocompatibility (H) antigens are the main targets of graft-versus-host and graft-versus-leukemia responses, we tested the hypothesis that multiparity could prime minor H antigen-specific T cells. We examined the peripheral lymphoid populations of multiparous mice and humans for evidence of priming of CD8+ T cytotoxic lymphocytes against peptide epitopes of the male-specific minor H antigen, HY. In contrast to naive females, multiparous females have measurable levels of circulating HY-specific tetramer-positive T lymphocytes, which can be readily expanded in vitro. These findings have implications for the in vitro generation of T cell clones as reagents for immunotherapy for tumours following stem cell transplantation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. S. Nielsen, R. Steffensen, K. Varming, A. G.S. Van Halteren, E. Spierings, L. P. Ryder, E. Goulmy, and O. B. Christiansen Association of HY-restricting HLA class II alleles with pregnancy outcome in patients with recurrent miscarriage subsequent to a firstborn boy Hum. Mol. Genet., May 1, 2009; 18(9): 1684 - 1691. 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