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Prepublished online as a Blood First Edition Paper on March 20, 2003; DOI 10.1182/blood-2002-10-3186.
Submitted October 24, 2002
Accepted March 10, 2003
CD8 + mouse spleen dendritic cells do not originate from the CD8- dendritic cell subset
Shalin Naik, David Vremec, Li Wu, Meredith O'Keeffe, and Ken Shortman*
Department of Immunology, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia
The Cooperative Research Centre for Vaccine Technology, Melbourne, VIC, Australia
* Corresponding author; email: shortman{at}wehi.edu.au.
Although previous studies had indicated that the CD8 - and CD8+ subtypes of murine dendritic cells (DC) differ in immediate origin, a recent study found that intravenous transfer of CD8- DC led to CD8+ DC in the spleen several days later, suggesting to a direct precursor-product relationship. We have repeated these experiments with a balance-sheet approach. We find that although a few CD8+ DC can be generated in such experiments, this is a rare event and could be due to a contaminant precursor. The vast majority of the immediate precursors of CD8+ DC are cells that lack the phenotype of a recognisable DC. CD8- DC and CD8+ DC are not precursor-product related, although these sublineages may be connected further upstream.
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