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Prepublished online as a Blood First Edition Paper on March 20, 2003; DOI 10.1182/blood-2002-10-3186. This Article Full Text (PDF) All Versions of this Article: 2002-10-3186v1 102/2/601    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Naik, S. Articles by Shortman, K. Search for Related Content PubMed PubMed Citation Articles by Naik, S. Articles by Shortman, K. Social Bookmarking                   What's this? Submitted October 24, 2002 Accepted March 10, 2003 CD8+ mouse spleen dendritic cells do not originate from the CD8- dendritic cell subset Shalin Naik, David Vremec, Li Wu, Meredith O'Keeffe, and Ken Shortman* Department of Immunology, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia The Cooperative Research Centre for Vaccine Technology, Melbourne, VIC, Australia * Corresponding author; email: shortman{at}wehi.edu.au. Although previous studies had indicated that the CD8- and CD8+ subtypes of murine dendritic cells (DC) differ in immediate origin, a recent study found that intravenous transfer of CD8- DC led to CD8+ DC in the spleen several days later, suggesting to a direct precursor-product relationship. We have repeated these experiments with a balance-sheet approach. We find that although a few CD8+ DC can be generated in such experiments, this is a rare event and could be due to a contaminant precursor. The vast majority of the immediate precursors of CD8+ DC are cells that lack the phenotype of a recognisable DC. CD8- DC and CD8+ DC are not precursor-product related, although these sublineages may be connected further upstream. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. K. Lee, M. Zamora, M. M. Linehan, N. Iijima, D. Gonzalez, A. Haberman, and A. Iwasaki Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection J. Exp. Med., February 16, 2009; 206(2): 359 - 370. [Abstract] [Full Text] [PDF] I. Caminschi, A. I. Proietto, F. Ahmet, S. Kitsoulis, J. Shin Teh, J. C. Y. Lo, A. Rizzitelli, L. Wu, D. Vremec, S. L. H. van Dommelen, et al. The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement Blood, October 15, 2008; 112(8): 3264 - 3273. [Abstract] [Full Text] [PDF] S. Sekine, K. Kataoka, Y. Fukuyama, Y. Adachi, J. 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