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Prepublished online as a Blood First Edition Paper on March 6, 2003; DOI 10.1182/blood-2002-10-3228. This Article Full Text (PDF) Supplemental Figure All Versions of this Article: 2002-10-3228v1 102/1/328    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Henderson, R. B Articles by Hogg, N. Search for Related Content PubMed PubMed Citation Articles by Henderson, R. B Articles by Hogg, N. Social Bookmarking                   What's this? Submitted October 24, 2002 Accepted February 19, 2003 Rapid recruitment of inflammatory monocytes is independent of neutrophil migration Robert B Henderson, Josie A R Hobbs, Meg Mathies, and Nancy Hogg* Leukocyte Adhesion Laboratory, Cancer Research UK London Research Institute, London, United Kingdom * Corresponding author; email: nancy.hogg{at}cancer.org.uk. Early neutrophil entry into an inflammatory site is thought to mediate a chemokine switch, inducing subsequent monocyte recruitment through the regulation of MCP-1 release. As the murine monocyte is poorly characterised and difficult to identify, there has been little examination of either its early recruitment in inflammatory models or of the factors that influence its early migration. The phenotyping of rapidly recruited inflammatory leukocytes with 7/4 and Gr-1 mAbs identifies two distinct populations, which we characterise as murine monocytes and neutrophils. Monocytes migrate in the first two hours of inflammation making use of 41, but not Mac-1 or LFA-1 integrins. Early migration is dependent on MCP-1, but neither MCP-1 release, nor monocyte recruitment is affected by the reduced neutrophil migration seen in LFA-1-/- mice. Endogenous peritoneal macrophages and mesothelial cells lining the peritoneum contain MCP-1, which is released following thioglycollate stimulation. The murine monocyte therefore responds rapidly to chemokines produced in situ by tissue cells at the site of inflammation with no requirement for prior influx of neutrophils. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y. Tanriver, A. Martin-Fontecha, K. Ratnasothy, G. Lombardi, and R. Lechler Superantigen-Activated Regulatory T Cells Inhibit the Migration of Innate Immune Cells and the Differentiation of Naive T Cells J. Immunol., September 1, 2009; 183(5): 2946 - 2956. 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