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Prepublished online as a Blood First Edition Paper on January 23, 2003; DOI 10.1182/blood-2002-10-3229. This Article Full Text (PDF) All Versions of this Article: 2002-10-3229v1 101/12/4862    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mahnke, K. Articles by Enk, A. H Search for Related Content PubMed PubMed Citation Articles by Mahnke, K. Articles by Enk, A. H Related Collections Related Article in Blood Online Social Bookmarking                   What's this? Submitted October 25, 2002 Accepted January 10, 2003 Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells Karsten Mahnke*, Yingjie Qian, Juergen Knop, and Alexander H Enk Department of Dermatology, University of Mainz, Mainz, Germany * Corresponding author; email: mahnke{at}hautklinik.klinik.uni-mainz.de. Coupling of ovalbumin (OVA) to anti-DEC-205 mAb (DEC) induced proliferation of OVA specific T cells in vivo. Expansion was short-lived, caused by DC, and rendered T cells anergic thereafter. Phenotypic analysis revealed induction of CD25+/CTLA-4+ T cells suppressing proliferation and IL-2 production of effector CD4+ T cells. The findings were supported by two disease models: (1) CD4+ T cell mediated hypersensitivity reactions were suppressed by injection of DEC-OVA and (2) application of hapten-coupled DEC-205 reduced CD8+ T cell mediated allergic reactions. Thus targeting of antigens to immature DC via DEC antibodies leads to induction of regulatory T cells, providing the basis for novel strategies to induce regulatory T cells in vivo. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Targeting DCs to induce regulatory T cells in vivo Robert L. Truitt Blood 2003 101: 4649-4650. [Full Text] [PDF] This article has been cited by other articles: L. K. Swee, N. Bosco, B. Malissen, R. Ceredig, and A. Rolink Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment Blood, June 18, 2009; 113(25): 6277 - 6287. [Abstract] [Full Text] [PDF] C. Ohnmacht, A. Pullner, S. B.S. King, I. Drexler, S. Meier, T. Brocker, and D. Voehringer Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells and results in spontaneous fatal autoimmunity J. Exp. Med., March 16, 2009; 206(3): 549 - 559. [Abstract] [Full Text] [PDF] C. 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