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Prepublished online as a Blood First Edition Paper on April 24, 2003; DOI 10.1182/blood-2002-10-3230. This Article Full Text (PDF) All Versions of this Article: 2002-10-3230v1 102/3/996    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mele, A. Articles by Franceschi, S. Search for Related Content PubMed PubMed Citation Articles by Mele, A. Articles by Franceschi, S. Social Bookmarking                   What's this? Submitted October 24, 2002 Accepted March 21, 2003 Hepatitis C virus and B-cell non-Hodgkin lymphomas: an Italian multi-center case-control study Alfonso Mele*, Alessandro Pulsoni, Elvira Bianco, Pellegrino Musto, Andre Szklo, Maria Grazia Sanpaolo, Emilio Iannitto, Amalia De Renzo, Bruno Martino, Vincenzo Liso, Cristina Andrizzi, Simona Pusterla, Fausto Dore, Maddalena Maresca, Maria Rapicetta, Fabrizio Marcucci, Franco Mandelli, and Silvia Franceschi Epidemiologia Clinica, Istituto Superiore di Sanita, Rome, Italy 'La Sapienza' University, Rome, Italy Department of Haematology, IRCCS 'Casa Sollievo e Sofferenza' Hospital, San Giovanni Rotondo, Italy Department of Haematology, University of Palermo, Palermo, Italy 'Federico II' University, Naples, Italy 'Riuniti' Hospital, Reggio Calabria, Italy Department of Haematology, University of Bari, Bari, Italy Department of Haematology, Montefiascone Hospital, Montefiascone, Italy 'Riuniti' Hospital, Bergamo, Italy University of Sassari, Sassari, Italy 'Catholic' University, Rome, Italy Chief, Unit of Field and Intervention Studies, International Agency for Research on Cancer, Lyon, France * Corresponding author; email: amele{at}iss.it. Background: The existence of an association between infection with hepatitis C virus (HCV) and B-cell non-Hodgkin Lymphoma (B-NHL) remains controversial, largely because previous studies were based on prevalent case-series or comparisons with less than optimal control groups. Objective: To evaluate the association between HCV infection and B-NHL of different type. Design: Hospital-based case-control study. Setting: Haematological departments of ten hospitals in different Italian cities. Patients and Methods: The study was conducted from January 1998 through February 2001. The cases consisted of consecutive patients with a new diagnosis of B-NHL; the controls were patients in other departments of the same hospitals. Both groups were interviewed using a standardised questionnaire. The prevalence of HCV infection was calculated by type of B-NHL and degree of histological differentiation (low grade and high grade). Adjusted odds ratios (OR) and HCV-attributable risk (AR) were estimated. Results: The HCV prevalence was 17.7% among the 401 cases and 5.6% among the 396 controls. The OR of B-NHL (cases vs. controls), adjusted by age, sex, level of education and place of birth, was 3.1 (95% Confidence Interval, IC 1.8-5.2); an OR indicative of positive association was also found for both low-grade and high-grade B-NHL. The estimated AR was 4.6%. Conclusions: The study confirms an association between HCV and B-NHL. In Italy one out of 20 of B-NHL may be attributable to HCV infection and may, thus, benefit of anti-viral treatment. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Paulli, L. Arcaini, M. Lucioni, E. Boveri, D. Capello, F. Passamonti, M. Merli, S. Rattotti, D. Rossi, R. Riboni, et al. Subcutaneous 'lipoma-like' B-cell lymphoma associated with HCV infection: a new presentation of primary extranodal marginal zone B-cell lymphoma of MALT Ann. 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