SEARCH:   Advanced

Prepublished online as a Blood First Edition Paper on January 30, 2003; DOI 10.1182/blood-2002-10-3236. This Article Full Text (PDF) Supplemental Tables All Versions of this Article: 2002-10-3236v1 101/11/4539    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sanchez-Izquierdo, D. Articles by Martinez-Climent, J. A Search for Related Content PubMed PubMed Citation Articles by Sanchez-Izquierdo, D. Articles by Martinez-Climent, J. A Social Bookmarking                   What's this? Submitted October 28, 2002 Accepted January 14, 2003 MALT1 is deregulated by both chromosomal translocation and amplification in B-cell non-Hodgkin lymphoma Dolors Sanchez-Izquierdo, Gerard Buchonet, Reiner Siebert, Randy D Gascoyne, Joan Climent, Loraine Karran, Miguel Marin, David Blesa, Douglas Horsman, Andreas Rosenwald, Louis M Staudt, Donna G Albertson, Ming-Quing Du, Hongtao Ye, Peter Marynen, Javier Garcia-Conde, Daniel Pinkel, Martin J S Dyer*, and Jose A Martinez-Climent Department of Hematology and Medical Oncology, Hospital Clinico, University of Valencia, Valencia, Spain Department of Haematology, University of Leicester, Leicester, United Kingdom Institute of Human Genetics, University Hospital Kiel, Kiel, Germany Department of Pathology, British Columbia Cancer Agency, Vancouver, BC, Canada Metabolism Branch, National Cancer Institute, Bethesda, MD, USA Cancer Research Institute, University of California San Francisco, San Francisco, CA, USA Department of Histopathology, University College London, London, United Kingdom Department of Histopathology, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Leuven, Belgium * Corresponding author; email: mjsd1{at}leicester.ac.uk. The MALT1 gene was identified through its involvement in t(11;18)(q21;q21), seen in 30% of cases of mucosa-associated lymphoid tissue (MALT) lymphoma. Here, we show that deregulated MALT1 expression may occur in B-cell non-Hodgkin lymphoma (B-NHL) of various histological subtypes either through translocation to the immunoglobulin heavy chain (IGH) locus or by genomic amplification. Firstly, two cases, one case of MALT lymphoma and another of aggressive marginal zone lymphoma (MZL) with t(14;18)(q32;q21), cytogenetically identical to the translocation involving BCL2, were shown by fluorescence in situ hybridization (FISH) to involve MALT1, which lies about 5Mb centromeric of BCL2. Molecular cloning of both by long-distance inverse PCR, showed breakpoints lying 1-2kb centromeric of the first 5' MALT1 exon; both cases showed MALT1 over-expression at either RNA and/or protein levels. Secondly, we examined the structure and gene expression profile of genomic amplifications involving 18q21 in a panel of 40 B-NHL cell lines using comparative genomic hybridization to microarrays (array CGH) and gene expression profiling techniques. Using array CGH, two peaks of genomic amplification were observed, one centered around BCL2 and the other around MALT1. Of the 3 cell lines with MALT1 amplification, 2 showed MALT1 over-expression as assessed by gene profiling, quantitative RT-PCR and western blotting. To determine if comparable events occurred in primary MALT and splenic MZL tumors, 40 cases were analyzed by FISH and/or quantitative RT-PCR; genomic amplification and MALT1 over-expression were seen in 2 cases. Together, these data implicate MALT1 as a dominant oncogene that may play a role in the pathogenesis of B-NHL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E C Obermann, M Csato, S Dirnhofer, and A Tzankov BCL2 gene aberration as an IPI-independent marker for poor outcome in non-germinal-centre diffuse large B cell lymphoma J. Clin. Pathol., October 1, 2009; 62(10): 903 - 907. [Abstract] [Full Text] [PDF] R. J. Bende, F. van Maldegem, and C. J.M. van Noesel Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas Haematologica, August 1, 2009; 94(8): 1109 - 1123. [Abstract] [Full Text] [PDF] I. Takeuchi, H. Tagawa, A. Tsujikawa, M. Nakagawa, M. Katayama-Suguro, Y. Guo, and M. Seto The potential of copy number gains and losses, detected by array-based comparative genomic hybridization, for computational differential diagnosis of B-cell lymphomas and genetic regions involved in lymphomagenesis Haematologica, January 1, 2009; 94(1): 61 - 69. [Abstract] [Full Text] [PDF] J. Dierlamm, E. M. Murga Penas, S. Bentink, S. Wessendorf, H. Berger, M. Hummel, W. Klapper, D. Lenze, A. Rosenwald, E. Haralambieva, et al. Gain of chromosome region 18q21 including the MALT1 gene is associated with the activated B-cell-like gene expression subtype and increased BCL2 gene dosage and protein expression in diffuse large B-cell lymphoma Haematologica, May 1, 2008; 93(5): 688 - 696. [Abstract] [Full Text] [PDF] Y. Zhou, H. Ye, J. I. Martin-Subero, S. Gesk, R. Hamoudi, Y.-J. Lu, R. Wang, J. Shipley, R. Siebert, P. G. Isaacson, et al. The pattern of genomic gains in salivary gland MALT lymphomas Haematologica, July 1, 2007; 92(7): 921 - 927. [Abstract] [Full Text] [PDF] H. Noels, G. van Loo, S. Hagens, V. Broeckx, R. Beyaert, P. Marynen, and M. Baens A Novel TRAF6 Binding Site in MALT1 Defines Distinct Mechanisms of NF-{kappa}B Activation by API2{middle dot}MALT1 Fusions J. Biol. Chem., April 6, 2007; 282(14): 10180 - 10189. [Abstract] [Full Text] [PDF] C. M Bacon, M.-Q. Du, and A. Dogan Mucosa-associated lymphoid tissue (MALT) lymphoma: a practical guide for pathologists J. Clin. Pathol., April 1, 2007; 60(4): 361 - 372. [Abstract] [Full Text] [PDF] C. Mestre-Escorihuela, F. Rubio-Moscardo, J. A. Richter, R. Siebert, J. Climent, V. Fresquet, E. Beltran, X. Agirre, I. Marugan, M. Marin, et al. Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas Blood, January 1, 2007; 109(1): 271 - 280. [Abstract] [Full Text] [PDF] M-Q Du and J C Atherton Molecular subtyping of gastric MALT lymphomas: implications for prognosis and management. Gut, June 1, 2006; 55(6): 886 - 893. [Full Text] [PDF] X. Sagaert, P. de Paepe, L. Libbrecht, V. Vanhentenrijk, G. Verhoef, J. Thomas, I. Wlodarska, and C. De Wolf-Peeters Forkhead Box Protein P1 Expression in Mucosa-Associated Lymphoid Tissue Lymphomas Predicts Poor Prognosis and Transformation to Diffuse Large B-Cell Lymphoma J. Clin. Oncol., June 1, 2006; 24(16): 2490 - 2497. [Abstract] [Full Text] [PDF] M. Baens, S. Fevery, X. Sagaert, H. Noels, S. Hagens, V. Broeckx, A. D. Billiau, C. De Wolf-Peeters, and P. Marynen Selective Expansion of Marginal Zone B Cells in E{micro}-API2-MALT1 Mice Is Linked to Enhanced I{kappa}B Kinase {gamma} Polyubiquitination. Cancer Res., May 15, 2006; 66(10): 5270 - 5277. [Abstract] [Full Text] [PDF] R. Dijkman, C. P. Tensen, E. S. Jordanova, J. Knijnenburg, J. J. Hoefnagel, A. A. Mulder, C. Rosenberg, A. K. Raap, R. Willemze, K. Szuhai, et al. Array-Based Comparative Genomic Hybridization Analysis Reveals Recurrent Chromosomal Alterations and Prognostic Parameters in Primary Cutaneous Large B-Cell Lymphoma J. Clin. Oncol., January 10, 2006; 24(2): 296 - 305. [Abstract] [Full Text] [PDF] M. Nakagawa, Y. Hosokawa, M. Yonezumi, K. Izumiyama, R. Suzuki, S. Tsuzuki, M. Asaka, and M. Seto MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10 Blood, December 15, 2005; 106(13): 4210 - 4216. [Abstract] [Full Text] [PDF] P. Farinha and R. D. Gascoyne Molecular Pathogenesis of Mucosa-Associated Lymphoid Tissue Lymphoma J. Clin. Oncol., September 10, 2005; 23(26): 6370 - 6378. [Abstract] [Full Text] [PDF] F. Bertoni and E. Zucca State-of-the-Art Therapeutics: Marginal-Zone Lymphoma J. Clin. Oncol., September 10, 2005; 23(26): 6415 - 6420. [Abstract] [Full Text] [PDF] E. Zucca and F. Bertoni Another Piece of the MALT Lymphomas Jigsaw J. Clin. Oncol., August 1, 2005; 23(22): 4832 - 4834. [Full Text] [PDF] F. Rubio-Moscardo, J. Climent, R. Siebert, M. A. Piris, J. I. Martin-Subero, I. Nielander, J. Garcia-Conde, M. J. S. Dyer, M. J. Terol, D. Pinkel, et al. Mantle-cell lymphoma genotypes identified with CGH to BAC microarrays define a leukemic subgroup of disease and predict patient outcome Blood, June 1, 2005; 105(11): 4445 - 4454. [Abstract] [Full Text] [PDF] L. Ho, R. E. Davis, B. Conne, R. Chappuis, M. Berczy, P. Mhawech, L. M. Staudt, and J. Schwaller MALT1 and the API2-MALT1 fusion act between CD40 and IKK and confer NF-{kappa}B-dependent proliferative advantage and resistance against FAS-induced cell death in B cells Blood, April 1, 2005; 105(7): 2891 - 2899. [Abstract] [Full Text] [PDF] H. Tagawa, S. Tsuzuki, R. Suzuki, S. Karnan, A. Ota, Y. Kameoka, M. Suguro, K. Matsuo, M. Yamaguchi, M. Okamoto, et al. Genome-Wide Array-Based Comparative Genomic Hybridization of Diffuse Large B-Cell Lymphoma: Comparison between CD5-Positive and CD5-Negative Cases Cancer Res., September 1, 2004; 64(17): 5948 - 5955. [Abstract] [Full Text] [PDF] Y. Hosokawa, H. Suzuki, Y. Suzuki, R. Takahashi, and M. Seto Antiapoptotic Function of Apoptosis Inhibitor 2-MALT1 Fusion Protein Involved in t(11;18)(q21;q21) Mucosa-Associated Lymphoid Tissue Lymphoma Cancer Res., May 15, 2004; 64(10): 3452 - 3457. [Abstract] [Full Text] [PDF] J Krugmann, A Tzankov, S Dirnhofer, F Fend, R Greil, R Siebert, and M Erdel Unfavourable prognosis of patients with trisomy 18q21 detected by fluorescence in situ hybridisation in t(11;18) negative, surgically resected, gastrointestinal B cell lymphomas J. Clin. Pathol., April 1, 2004; 57(4): 360 - 364. [Abstract] [Full Text] [PDF] G. A. Calin, C. Sevignani, C. D. Dumitru, T. Hyslop, E. Noch, S. Yendamuri, M. Shimizu, S. Rattan, F. Bullrich, M. Negrini, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers PNAS, March 2, 2004; 101(9): 2999 - 3004. [Abstract] [Full Text] [PDF] S. Wohlfart, D. Sebinger, P. Gruber, J. Buch, D. Polgar, G. Krupitza, M. Rosner, M. Hengstschlager, M. Raderer, A. Chott, et al. FAS (CD95) Mutations Are Rare in Gastric MALT Lymphoma but Occur More Frequently in Primary Gastric Diffuse Large B-Cell Lymphoma Am. J. Pathol., March 1, 2004; 164(3): 1081 - 1089. [Abstract] [Full Text] [PDF] C. Schwaenen, M. Nessling, S. Wessendorf, T. Salvi, G. Wrobel, B. Radlwimmer, H. A. Kestler, C. Haslinger, S. Stilgenbauer, H. Dohner, et al. Automated array-based genomic profiling in chronic lymphocytic leukemia: Development of a clinical tool and discovery of recurrent genomic alterations PNAS, January 27, 2004; 101(4): 1039 - 1044. [Abstract] [Full Text] [PDF] B. Streubel, D. Huber, S. Wohrer, A. Chott, and M. Raderer Frequency of Chromosomal Aberrations Involving MALT1 in Mucosa-Associated Lymphoid Tissue Lymphoma in Patients with Sjogren's Syndrome Clin. Cancer Res., January 15, 2004; 10(2): 476 - 480. [Abstract] [Full Text] [PDF] G. Ghannam, A. Takeda, T. Camarata, M. A. Moore, A. Viale, and N. R. Yaseen The Oncogene Nup98-HOXA9 Induces Gene Transcription in Myeloid Cells J. Biol. Chem., January 9, 2004; 279(2): 866 - 875. [Abstract] [Full Text] [PDF] S. A. Pileri, P. L. Zinzani, P. Went, A. Pileri Jr, and M. Bendandi Indolent lymphoma: the pathologist's viewpoint Ann. Onc., January 1, 2004; 15(1): 12 - 18. [Abstract] [Full Text] [PDF] D. G. Albertson and D. Pinkel Genomic microarrays in human genetic disease and cancer Hum. Mol. Genet., October 15, 2003; 12(90002): R145 - 152. [Abstract] [Full Text] [PDF] A. Conconi, G. Martinelli, C. Thieblemont, A. J. M. Ferreri, L. Devizzi, F. Peccatori, M. Ponzoni, E. Pedrinis, S. Dell'Oro, G. Pruneri, et al. Clinical activity of rituximab in extranodal marginal zone B-cell lymphoma of MALT type Blood, October 15, 2003; 102(8): 2741 - 2745. [Abstract] [Full Text] [PDF]

	Copyright © 2003 by American Society of Hematology         Online ISSN: 1528-0020