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Prepublished online as a Blood First Edition Paper on April 17, 2003; DOI 10.1182/blood-2002-11-3333. This Article Full Text (PDF) All Versions of this Article: 2002-11-3333v1 102/3/1070    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Robillard, N. Articles by Bataille, R. Search for Related Content PubMed PubMed Citation Articles by Robillard, N. Articles by Bataille, R. Social Bookmarking                   What's this? Submitted November 4, 2002 Accepted January 29, 2003 CD20 is associated with a small mature plasma-cell morphology and t(11;14) in multiple myeloma Nelly Robillard, Herve Avet-Loiseau, Richard Garand, Philippe Moreau, Danielle Pineau, Marie-Josee Rapp, Jean-Luc Harousseau, and Regis Bataille* Laboratory of Hematology, Institute of Biology, Nantes, France Laboratory of Hematology, Institute of Biology, Nantes, France; Inserm U463, Institute of Biology, Nantes, France Clinical Hematology, Hotel Dieu, Nantes, France Laboratory of Hematology, Institute of Biology, Nantes, France; Inserm U463, Institute of Biology, Nantes, France; Clinical Hematology, Hotel Dieu, Nantes, France * Corresponding author; email: frb{at}nantes.inserm.fr. CD20 has been re-investigated in Multiple Myeloma (MM) in 66 patients with MM. 12/66 (18 %) do express CD20, including 5 of 50 patients at diagnosis presenting 100% CD20 + cells. Seven of 12 (58%) CD20+ MM have a small mature plasma-cell morphology as opposed to 4/54 (7%) CD20-MM (p=.0001). Of note, 10/12 ( 83% ) CD20 + MM present t(11;14) as opposed to 5/54 (9%) CD20 _ patients (p<.001). All the patients with 100% CD20+ cells present with a t( 11 ; 14 ) and 4 of 5 with a small mature plasma cell morphology. Thus 66% of the patients with t(11;14) do express CD20 whereas only 4% of the 51 patients lacking such translocation do express CD20 (p<.0001). In conclusion, CD20 expression is associated with small mature plasma-cell morphology and with t(11;14) in MM. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: N-T Ngo, C Brodie, C Giles, D Horncastle, M Klammer, I A Lampert, A Rahemtulla, and K N Naresh The significance of tumour cell immunophenotype in myeloma and its impact on clinical outcome J. Clin. Pathol., November 1, 2009; 62(11): 1009 - 1015. 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