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Prepublished online as a Blood First Edition Paper on January 16, 2003; DOI 10.1182/blood-2002-11-3353. This Article Full Text (PDF) All Versions of this Article: 2002-11-3353v1 101/10/4000    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Stebbing, J. Articles by Patterson, S. Search for Related Content PubMed PubMed Citation Articles by Stebbing, J. Articles by Patterson, S. Social Bookmarking                   What's this? Submitted November 6, 2002 Accepted December 24, 2002 The heat shock protein receptor CD91 is upregulated in monocytes of HIV-1-infected "true" long-term non-progressors Justin Stebbing*, Brian Gazzard, Louise Kim, Simon Portsmouth, Adrian Wildfire, Ian Teo, Mark Nelson, Mark Bower, Frances Gotch, Sunil Shaunak, Pramod Srivastava, and Steve Patterson Division of Investigative Science, Department of Immunology, Chelsea and Westminster Hospital, London, United Kingdom Division of Investigative Science, Department of Infectious Diseases, Hammersmith Hospital, London, United Kingdom Center for Immunotherapy of Cancer and Infectious Diseases, University of Conneticut, Farmington, CT, USA * Corresponding author; email: j.stebbing{at}ic.ac.uk. A small proportion of human immunodeficiency virus type 1 (HIV-1) infected individuals remain asymptomatic for a long period post infection. It is thought that a vigorous immune response may contribute to long term non progression although studies are confounded by heterogeneity among patients. We studied the levels of HIV-1 receptors, co-stimulatory T cell molecules and dendritic cell (DC) numbers in 18 individuals with long term infection, a CD4 count > 400 cells/mm3 and an HIV-1 viral load < 50 copies/mL. These patients were further differentiated by the presence or absence of 2-LTR DNA circles, a possible marker for residual ongoing HIV-1 replication. A statistically significant increase in levels of CD91, the heat shock protein (HSP) receptor, was observed in therapy naive individuals who had no evidence of ongoing viral replication (p = 0.01). This difference was most notable on their monocytes. High levels of CD91 may be a host factor that contributes to maintenance of long term non progression. Its ability to internalise -defensins and cross present exogenous antigen to cytotoxic T lymphocytes via MHC class I may maintain CD8+ responses in these individuals. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: X. Gong, W. Gai, J. Xu, W. Zhou, and P. Tien Glycoprotein 96-Mediated Presentation of Human Immunodeficiency Virus Type 1 (HIV-1)-Specific Human Leukocyte Antigen Class I-Restricted Peptide and Humoral Immune Responses to HIV-1 p24 Clin. Vaccine Immunol., November 1, 2009; 16(11): 1595 - 1600. [Abstract] [Full Text] [PDF] E. Acheampong, Z. Parveen, A. Mengistu, N. Ngoubilly, B. Wigdahl, A. S. Lossinsky, R. J. Pomerantz, and M. Mukhtar Cholesterol-Depleting Statin Drugs Protect Postmitotically Differentiated Human Neurons against Ethanol- and Human Immunodeficiency Virus Type 1-Induced Oxidative Stress In Vitro J. Virol., February 1, 2007; 81(3): 1492 - 1501. [Abstract] [Full Text] [PDF] J. 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Patterson, M. Bower, D. Perumal, M. Nelson, A. McMichael, G. Ogg, A. Epenetos, F. Gotch, et al. Antibody-targeted MHC complex-directed expansion of HIV-1- and KSHV-specific CD8+ lymphocytes: a new approach to therapeutic vaccination Blood, March 1, 2004; 103(5): 1791 - 1795. [Abstract] [Full Text] [PDF] J. Stebbing, P. Savage, S. Patterson, and B. Gazzard All for CD91 and CD91 for all J. Antimicrob. Chemother., January 1, 2004; 53(1): 1 - 3. [Abstract] [Full Text] [PDF] J. Stebbing, B. Gazzard, S. Portsmouth, F. Gotch, L. Kim, M. Bower, S. Mandalia, R. Binder, P. Srivastava, and S. Patterson Disease-associated dendritic cells respond to disease-specific antigens through the common heat shock protein receptor Blood, September 1, 2003; 102(5): 1806 - 1814. [Abstract] [Full Text] [PDF]

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