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Blood, 1 May 2004, Vol. 103, No. 9, pp. 3599-3602. Prepublished online as a Blood First Edition Paper on December 30, 2003; DOI 10.1182/blood-2002-11-3568. This Article Full Text (PDF) All Versions of this Article: 2002-11-3568v1 103/9/3599    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Keen, L. J Articles by Hows, J. M Search for Related Content PubMed PubMed Citation Articles by Keen, L. J Articles by Hows, J. M Social Bookmarking                   What's this? Submitted December 3, 2002 Accepted December 2, 2003 Interleukin-10 and tumor necrosis factor alpha region haplotypes predict transplant mortality after unrelated donor stem cell transplantation Leigh J Keen, Todd E DeFor, Jeffrey L Bidwell, Stella M Davies, Benjamin A Bradley, and Jill M Hows* Department of Pathology and Microbiology, University of Bristol, Bristol, United Kingdom Department of Bone Marrow Transplantation and Clinical Research, University of Minnesota, Minneapolis, MN, USA Division of Transplantation Sciences, University of Bristol, Bristol, United Kingdom * Corresponding author; email: jill.hows{at}bristol.ac.uk. Cytokine gene polymorphisms correlate with outcome of HLA identical sibling stem cell transplantation (ID-SCT). This has not been extensively investigated in unrelated donor SCT (UD-SCT). We studied the association between tumor necrosis alpha (TNF-) and interleukin-10 (IL-10) polymorphisms and transplant related mortality (TRM) at one year in 182 UD-SCT performed at a single center. Both TNFd4 allele and TNF- 1031C alleles were associated with TRM. Statistical analysis showed that both polymorphisms were part of a single haplotype associated with increased TRM at one year when present in recipient or donor, 55% (43-67%) compared with 21% (12-30%) when absent from both, (p = 0.003). Presence of the donor IL-10 R2-(IL-10G)-G-C-C haplotype was associated with increased risk of TRM, 61% (43-79%) compared with 34% (25-43%), p=0.01. In contrast the R3- (IL-10)-G-C-C haplotypes associated with reduced risk of TRM, 30% (19-41%) compared with 53% (40-66%), p=0.01. Results were confirmed by multifactorial methods. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M.-T. Lin, B. Storer, P. J. Martin, L.-H. Tseng, B. Grogan, P.-J. Chen, L. P. Zhao, and J. A. Hansen Genetic variation in the IL-10 pathway modulates severity of acute graft-versus-host disease following hematopoietic cell transplantation: synergism between IL-10 genotype of patient and IL-10 receptor {beta} genotype of donor Blood, December 1, 2005; 106(12): 3995 - 4001. [Abstract] [Full Text] [PDF]

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