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Prepublished online as a Blood First Edition Paper on March 6, 2003; DOI 10.1182/blood-2002-12-3647. This Article Full Text (PDF) All Versions of this Article: 2002-12-3647v1 101/12/4667    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Platanias, L. C Search for Related Content PubMed PubMed Citation Articles by Platanias, L. C Social Bookmarking                   What's this? Submitted December 3, 2002 Accepted January 31, 2003 Map kinase signaling pathways and hematologic malignancies Leonidas C Platanias* Robert H. Lurie Comprehensive Cancer Center and Division of Hematology-Oncology, Northwestern University Medical School, Chicago, IL, USA * Corresponding author; email: l-platanias{at}northwestern.edu. Mitogen-activated protein (MAP) kinases are widely expressed serine-threonine kinases that mediate important regulatory signals in the cell. Three major groups of MAP kinase exist: the p38 MAP kinase family, the extracellular signal-regulated (Erk) kinase family and the c-Jun NH2-terminal kinase (JNK) family. The members of the different MAP kinase groups participate in the generation of various cellular responses, including gene transcription, induction of cell death or maintenance of cell survival, malignant transformation, and regulation of cell-cycle progression. Depending on the specific family-isoform involved and the cellular context, MAP kinase-pathways can mediate signals that either promote or suppress the growth of malignant hematopoietic cells. Over the last few years, extensive work by several groups has established that Map kinase pathways play critical roles in the pathogenesis of various hematologic malignancies, providing new molecular targets for future therapeutic approaches. In this review, the involvement of various MAP kinase pathways in the pathophysiology of hematologic malignances is summarized and the clinical implications of the recent advances in the field are discussed. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. K. Zaidi, C. R. Dowdy, A. J. van Wijnen, J. B. Lian, A. Raza, J. L. Stein, C. M. Croce, and G. S. Stein Altered Runx1 Subnuclear Targeting Enhances Myeloid Cell Proliferation and Blocks Differentiation by Activating a miR-24/MKP-7/MAPK Network Cancer Res., November 1, 2009; 69(21): 8249 - 8255. [Abstract] [Full Text] [PDF] C. R. Geest and P. J. 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