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Prepublished online as a Blood First Edition Paper on April 24, 2003; DOI 10.1182/blood-2002-12-3714. This Article Full Text (PDF) All Versions of this Article: 2002-12-3714v1 102/4/1232    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Suciu, S. Articles by Willemze, R. Search for Related Content PubMed PubMed Citation Articles by Suciu, S. Articles by Willemze, R. Social Bookmarking                   What's this? Submitted December 5, 2002 Accepted April 9, 2003 Allogeneic compared to autologous stem cell transplantation in the treatment of patients < 46 years old with acute myeloid leukemia (AML) in first complete remission (CR1): an intention to treat analysis of the EORTC/GIMEMA AML-10 trial Stefan Suciu*, Franco Mandelli, Theo de Witte, Robert Zittoun, Eugenio Gallo, Boris Labar, Gennaro De Rosa, Amine Belhabri, Rosario Giustolisi, Richard Delarue, Vincenzo Liso, Salvatore Mirto, Giuseppe Leone, Jean-Henri Bourhis, Giuseppe Fioritoni, Ulrich Jehn, Sergio Amadori, Paola Fazi, Anne Hagemeijer, and Roel Willemze EORTC Data Center, Brussels, Belgium Department of Cellular Biotechnology and Hematology, University La Sapienza, Rome, Italy Department of Hematology, St Radboud University Hospital, Nijmegen, The Netherlands Department of Hematology, Hotel-Dieu, Paris, France Department of Medicine, S. Giovanni Battista, Turin, Italy Department of Hematology, University Hospital Rebro, Zagreb, Croatia (Hrvatska) Department of Hematology, University Federico II Medical School, Naples, Italy Department of Hematology, Hospital Edouard Herriot, Lyon, France Department of Hematology, Hospital Ferrarotto, Catania, Italy Department of Hematology, Hospital Necker, Paris, France Department of Hematology, University degli Study di Bari, Bari, Italy Department of Hematology, Cervello, Palermo, Italy Department of Hematology, Catholic University, Rome, Italy Department of Hematology, Institut Gustave Roussy, Villejuif, France Department of Hematology, Civil Hospital, Pescara, Italy Department of Hematology, Klinikum Grosshadern Ludwig-Maximilians, Muenchen, Germany Department of Hematology, University Tor Vergata, Rome, Italy GIMEMA Data Center, Department of Cellular Biotechnology and Hematology, University La Sapienza, Rome, Italy Center for Human Genetics, University of Leuven, Leuven, Belgium Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands * Corresponding author; email: ssu{at}eortc.be. In the EORTC-LG/GIMEMA AML-10 trial, patients (pts) in CR1 received a single intensive consolidation (IC) course. Subsequently, those < 46 years old with an HLA identical sibling donor were assigned to undergo allogeneic (allo) stem cell transplantation (SCT) and pts without such a donor were planned for autologous (auto) SCT. Between 11.1993 and 12.1999, out of 1198 pts aged < 46 years, 822 achieved CR. 734 pts, constituting the study group, received IC: 293 had a sibling donor and 441 had not. Allo-SCT and auto-SCT was performed in 68.9% and 55.8%, respectively. Cytogenetics was successfully performed in 446 pts. Risk groups were: good (t(8;21), inv(16)), intermediate (NN or -Y only), bad/very bad (all others). Median follow-up was 4 years; 289 pts relapsed, 66 died in CR1, and 293 died. Intention-to-treat analysis revealed that the 4-year disease-free survival (DFS) rate of pts with a donor vs of those without a donor was 52.2% vs 42.2%, p=0.044; hazard ratio=0.80, 95% confidence interval (0.64 , 0.995), the relapse incidence was 30.4% vs 52.5%, death in CR1 was 17.4% vs 5.3%, and the survival rate was 58.3% vs 50.8% (p=0.18). The DFS rates in pts with and without a sibling donor were similar in pts with good/intermediate risk, but 43.4% and 18.4%, respectively, in pts with bad/very bad risk cytogenetics. In younger patients (15-35 yrs), the difference was more pronounced. The strategy to perform early allo-SCT led to better overall results than auto-SCT, especially for younger patients or those with bad/very bad risk cytogenetics. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Tang, P. Hirsch, F. Fava, S. Lapusan, C. Marzac, I. Teyssandier, J. Pardo, J.-P. Marie, and O. 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