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Prepublished online as a Blood First Edition Paper on March 20, 2003; DOI 10.1182/blood-2002-12-3882. This Article Full Text (PDF) All Versions of this Article: 2002-12-3882v1 102/2/449    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Nieswandt, B. Articles by Watson, S. P Search for Related Content PubMed PubMed Citation Articles by Nieswandt, B. Articles by Watson, S. P Social Bookmarking                   What's this? Submitted December 23, 2002 Accepted March 5, 2003 Platelet collagen interaction: is GPVI the central receptor? Bernhard Nieswandt* and Steve P Watson Department of Vascular Biology, Rudolf Virchow Center for Experimental Biomedicine, Wuerzburg, Germany Division of Medical Sciences, The Medical School, University of Birmingham, Birmingham, United Kingdom * Corresponding author; email: bernhard.nieswandt{at}virchow.uni-wuerzburg.de. At sites of vascular injury, platelets come into contact with subendothelial collagen which triggers their activation and the formation of a hemostatic plug. Besides GPIb and IIb3 integrin which indirectly interact with collagen via von Willebrand factor (vWf), several collagen receptors have been identified on platelets, most notably 21 integrin and the Ig superfamily member GPVI. Within the last few years, major advances have been made in understanding platelet-collagen interactions including the molecular cloning of GPVI, the generation of mouse strains lacking individual collagen receptors, and the development of collagen receptor-specific antibodies and synthetic peptides. It is now recognized that platelet adhesion to collagen requires prior activation of integrins through "inside-out" signals generated by GPVI and reinforced by released second wave mediators ADP and thromboxane A2. These developments have lead to revision of the original "two-site, two-step" model which now places GPVI in a central position in the complex processes of platelet tethering, activation, adhesion, aggregation, degranulation, and procoagulant activity on collagen. This review discusses these recent developments and proposes possible mechanisms for how GPVI acts in concert with other receptors and signaling pathways to initiate hemostasis and arterial thrombosis. 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Small-molecule inhibitors of integrin {alpha}2{beta}1 that prevent pathological thrombus formation via an allosteric mechanism PNAS, January 20, 2009; 106(3): 719 - 724. [Abstract] [Full Text] [PDF] J. Mori, A. C. Pearce, J. C. Spalton, B. Grygielska, J. A. Eble, M. G. Tomlinson, Y. A. Senis, and S. P. Watson G6b-B Inhibits Constitutive and Agonist-induced Signaling by Glycoprotein VI and CLEC-2 J. Biol. Chem., December 19, 2008; 283(51): 35419 - 35427. [Abstract] [Full Text] [PDF] G. Stoll, C. Kleinschnitz, and B. Nieswandt Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment Blood, November 1, 2008; 112(9): 3555 - 3562. [Abstract] [Full Text] [PDF] T. Schonberger, D. Siegel-Axel, R. Bussl, S. Richter, M. S. Judenhofer, R. Haubner, G. Reischl, K. Klingel, G. Munch, P. Seizer, et al. The immunoadhesin glycoprotein VI-Fc regulates arterial remodelling after mechanical injury in ApoE-/- mice Cardiovasc Res, October 1, 2008; 80(1): 131 - 137. [Abstract] [Full Text] [PDF] S. M. Cifuni, D. D. Wagner, and W. Bergmeier CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin {alpha}IIb{beta}3 in platelets Blood, September 1, 2008; 112(5): 1696 - 1703. [Abstract] [Full Text] [PDF] H. Nishikii, K. Eto, N. Tamura, K. Hattori, B. Heissig, T. Kanaji, A. Sawaguchi, S. Goto, J. Ware, and H. Nakauchi Metalloproteinase regulation improves in vitro generation of efficacious platelets from mouse embryonic stem cells J. Exp. Med., August 4, 2008; 205(8): 1917 - 1927. [Abstract] [Full Text] [PDF] H. F. Langer, R. Haubner, B. J. Pichler, and M. Gawaz Radionuclide imaging a molecular key to the atherosclerotic plaque. J. Am. Coll. Cardiol., July 1, 2008; 52(1): 1 - 12. [Abstract] [Full Text] [PDF] M. A. Cejas, W. A. Kinney, C. Chen, J. G. Vinter, H. R. Almond Jr., K. M. Balss, C. A. Maryanoff, U. Schmidt, M. Breslav, A. Mahan, et al. Thrombogenic collagen-mimetic peptides: Self-assembly of triple helix-based fibrils driven by hydrophobic interactions PNAS, June 24, 2008; 105(25): 8513 - 8518. [Abstract] [Full Text] [PDF] O. Inoue, K. Suzuki-Inoue, and Y. Ozaki Redundant Mechanism of Platelet Adhesion to Laminin and Collagen under Flow: INVOLVEMENT OF VON WILLEBRAND FACTOR AND GLYCOPROTEIN Ib-IX-V J. Biol. Chem., June 13, 2008; 283(24): 16279 - 16282. [Abstract] [Full Text] [PDF] G. E. Jarvis, N. Raynal, J. P. Langford, D. J. Onley, A. Andrews, P. A. Smethurst, and R. W. Farndale Identification of a major GpVI-binding locus in human type III collagen Blood, May 15, 2008; 111(10): 4986 - 4996. [Abstract] [Full Text] [PDF] Z. A. Karim, W. Choi, and S. W. 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Matsuoka Inhibition of collagen-induced platelet aggregation by anopheline antiplatelet protein, a saliva protein from a malaria vector mosquito Blood, February 15, 2008; 111(4): 2007 - 2014. [Abstract] [Full Text] [PDF] E. E. Gardiner, D. Karunakaran, J. F. Arthur, F.-T. Mu, M. S. Powell, R. I. Baker, P. M. Hogarth, M. L. Kahn, R. K. Andrews, and M. C. Berndt Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: de-ITAM-izing Fc{gamma}RIIa Blood, January 1, 2008; 111(1): 165 - 174. [Abstract] [Full Text] [PDF] B. Nieswandt, M. Moser, I. Pleines, D. Varga-Szabo, S. Monkley, D. Critchley, and R. Fassler Loss of talin1 in platelets abrogates integrin activation, platelet aggregation, and thrombus formation in vitro and in vivo J. Exp. Med., December 24, 2007; 204(13): 3113 - 3118. [Abstract] [Full Text] [PDF] A. Kauskot, F. Adam, A. Mazharian, N. Ajzenberg, E. Berrou, A. Bonnefoy, J.-P. Rosa, M. F. Hoylaerts, and M. Bryckaert Involvement of the Mitogen-activated Protein Kinase c-Jun NH2-terminal Kinase 1 in Thrombus Formation J. Biol. Chem., November 2, 2007; 282(44): 31990 - 31999. [Abstract] [Full Text] [PDF] J. F. Arthur, Y. Shen, M. L. Kahn, M. C. Berndt, R. K. Andrews, and E. E. Gardiner Ligand Binding Rapidly Induces Disulfide-dependent Dimerization of Glycoprotein VI on the Platelet Plasma Membrane J. Biol. Chem., October 19, 2007; 282(42): 30434 - 30441. [Abstract] [Full Text] [PDF] A. Ragab, S. Severin, M.-P. Gratacap, E. Aguado, M. Malissen, M. Jandrot-Perrus, B. Malissen, J. Ragab-Thomas, and B. Payrastre Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC{gamma}2 activation Blood, October 1, 2007; 110(7): 2466 - 2474. [Abstract] [Full Text] [PDF] E. Calvo, F. Tokumasu, O. Marinotti, J.-L. Villeval, J. M. C. Ribeiro, and I. M. B. 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Nieswandt Diverging signaling events control the pathway of GPVI down-regulation in vivo Blood, July 15, 2007; 110(2): 529 - 535. [Abstract] [Full Text] [PDF] K. Furukawa, H. Fujiwara, Y. Sato, B.-X. Zeng, H. Fujii, S. Yoshioka, E. Nishi, and T. Nishio Platelets Are Novel Regulators of Neovascularization and Luteinization during Human Corpus Luteum Formation Endocrinology, July 1, 2007; 148(7): 3056 - 3064. [Abstract] [Full Text] [PDF] R. K. Andrews, D. Karunakaran, E. E. Gardiner, and M. C. Berndt Platelet Receptor Proteolysis: A Mechanism for Downregulating Platelet Reactivity Arterioscler Thromb Vasc Biol, July 1, 2007; 27(7): 1511 - 1520. [Abstract] [Full Text] [PDF] Z. M. Ruggeri and G. L. Mendolicchio Adhesion Mechanisms in Platelet Function Circ. Res., June 22, 2007; 100(12): 1673 - 1685. [Abstract] [Full Text] [PDF] H. Li, S. Lockyer, A. Concepcion, X. Gong, H. Takizawa, M. Guertin, Y. Matsumoto, J. Kambayashi, N. N. Tandon, and Y. Liu The Fab Fragment of a Novel Anti-GPVI Monoclonal Antibody, OM4, Reduces In Vivo Thrombosis Without Bleeding Risk in Rats Arterioscler Thromb Vasc Biol, May 1, 2007; 27(5): 1199 - 1205. [Abstract] [Full Text] [PDF] C. Grothusen, S. Umbreen, I. Konrad, K. Stellos, C. Schulz, B. Schmidt, E. Kremmer, O. Teebken, S. Massberg, M. Luchtefeld, et al. EXP3179 Inhibits Collagen-Dependent Platelet Activation via Glycoprotein Receptor-VI Independent of AT1-Receptor Antagonism: Potential Impact on Atherothrombosis Arterioscler Thromb Vasc Biol, May 1, 2007; 27(5): 1184 - 1190. [Abstract] [Full Text] [PDF] C. Kleinschnitz, M. Pozgajova, M. Pham, M. Bendszus, B. Nieswandt, and G. Stoll Targeting Platelets in Acute Experimental Stroke: Impact of Glycoprotein Ib, VI, and IIb/IIIa Blockade on Infarct Size, Functional Outcome, and Intracranial Bleeding Circulation, May 1, 2007; 115(17): 2323 - 2330. [Abstract] [Full Text] [PDF] U. J.H. Sachs and B. Nieswandt In Vivo Thrombus Formation in Murine Models Circ. Res., April 13, 2007; 100(7): 979 - 991. [Abstract] [Full Text] [PDF] C. V. Denis and D. D. Wagner Platelet Adhesion Receptors and Their Ligands in Mouse Models of Thrombosis Arterioscler Thromb Vasc Biol, April 1, 2007; 27(4): 728 - 739. [Abstract] [Full Text] [PDF] N. Bassler, C. Loeffler, P. Mangin, Y. Yuan, M. Schwarz, C. E. Hagemeyer, S. U. Eisenhardt, I. Ahrens, C. Bode, S. P. Jackson, et al. A Mechanistic Model for Paradoxical Platelet Activation by Ligand-Mimetic {alpha}IIb{beta}3 (GPIIb/IIIa) Antagonists Arterioscler Thromb Vasc Biol, March 1, 2007; 27(3): E9 - E15. [Abstract] [Full Text] [PDF] M. J. Maxwell, E. Westein, W. S. Nesbitt, S. Giuliano, S. M. Dopheide, and S. P. Jackson Identification of a 2-stage platelet aggregation process mediating shear-dependent thrombus formation Blood, January 15, 2007; 109(2): 566 - 576. [Abstract] [Full Text] [PDF] P. A. Smethurst, D. J. Onley, G. E. Jarvis, M. N. O'Connor, C. G. Knight, A. B. Herr, W. H. Ouwehand, and R. W. Farndale Structural Basis for the Platelet-Collagen Interaction: THE SMALLEST MOTIF WITHIN COLLAGEN THAT RECOGNIZES AND ACTIVATES PLATELET GLYCOPROTEIN VI CONTAINS TWO GLYCINE-PROLINE-HYDROXYPROLINE TRIPLETS J. Biol. Chem., January 12, 2007; 282(2): 1296 - 1304. [Abstract] [Full Text] [PDF] C. Strassel, C. Nonne, A. Eckly, T. David, C. Leon, M. Freund, J.-P. Cazenave, C. Gachet, and F. Lanza Decreased Thrombotic Tendency in Mouse Models of the Bernard-Soulier Syndrome Arterioscler Thromb Vasc Biol, January 1, 2007; 27(1): 241 - 247. [Abstract] [Full Text] [PDF] F. A. Lee, M. van Lier, I. A. M. Relou, L. Foley, J.-W. N. Akkerman, H. F. G. Heijnen, and R. W. Farndale Lipid Rafts Facilitate the Interaction of PECAM-1 with the Glycoprotein VI-FcR {gamma}-Chain Complex in Human Platelets J. Biol. Chem., December 22, 2006; 281(51): 39330 - 39338. [Abstract] [Full Text] [PDF] S. Offermanns Activation of Platelet Function Through G Protein-Coupled Receptors Circ. Res., December 8, 2006; 99(12): 1293 - 1304. [Abstract] [Full Text] [PDF] F. F. Samaha and M. L. Kahn Novel Platelet and Vascular Roles for Immunoreceptor Signaling Arterioscler Thromb Vasc Biol, December 1, 2006; 26(12): 2588 - 2593. [Abstract] [Full Text] [PDF] W. Bergmeier, C. L. Piffath, T. Goerge, S. M. Cifuni, Z. M. Ruggeri, J. Ware, and D. D. Wagner The role of platelet adhesion receptor GPIb{alpha} far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis PNAS, November 7, 2006; 103(45): 16900 - 16905. [Abstract] [Full Text] [PDF] J. M. E. M. Cosemans, I. C. A. Munnix, R. Wetzker, R. Heller, S. P. Jackson, and J. W. M. Heemskerk Continuous signaling via PI3K isoforms beta and {gamma} is required for platelet ADP receptor function in dynamic thrombus stabilization Blood, November 1, 2006; 108(9): 3045 - 3052. [Abstract] [Full Text] [PDF] B. Ibanez, G. Vilahur, and J. J. Badimon Pharmacology of thienopyridines: rationale for dual pathway inhibition Eur. Heart J. Suppl., October 1, 2006; 8(suppl_G): G3 - G9. [Abstract] [Full Text] [PDF] J. Cho and D. F. Mosher Impact of fibronectin assembly on platelet thrombus formation in response to type I collagen and von Willebrand factor Blood, October 1, 2006; 108(7): 2229 - 2236. [Abstract] [Full Text] [PDF] B. Bigalke, S. Lindemann, R. Ehlers, P. Seizer, K. Daub, H. Langer, T. Schonberger, E. Kremmer, D. Siegel-Axel, A. E. May, et al. Expression of platelet collagen receptor glycoprotein VI is associated with acute coronary syndrome Eur. Heart J., September 2, 2006; 27(18): 2165 - 2169. [Abstract] [Full Text] [PDF] A. Zahn, N. Jennings, W. H. Ouwehand, and J.-P. Allain Hepatitis C virus interacts with human platelet glycoprotein VI. J. Gen. Virol., August 1, 2006; 87(Pt 8): 2243 - 2251. [Abstract] [Full Text] [PDF] B. Boylan, M. C. Berndt, M. L. Kahn, and P. J. Newman Activation-independent, antibody-mediated removal of GPVI from circulating human platelets: development of a novel NOD/SCID mouse model to evaluate the in vivo effectiveness of anti-human platelet agents Blood, August 1, 2006; 108(3): 908 - 914. [Abstract] [Full Text] [PDF] M. Pozgajova, U. J. H. Sachs, L. Hein, and B. Nieswandt Reduced thrombus stability in mice lacking the {alpha}2A-adrenergic receptor Blood, July 15, 2006; 108(2): 510 - 514. [Abstract] [Full Text] [PDF] V. Schulte, H. P. Reusch, M. Pozgajova, D. Varga-Szabo, C. Gachet, and B. Nieswandt Two-Phase Antithrombotic Protection After Anti-Glycoprotein VI Treatment in Mice Arterioscler Thromb Vasc Biol, July 1, 2006; 26(7): 1640 - 1647. [Abstract] [Full Text] [PDF] P. Mangin, C. L. Yap, C. Nonne, S. A. Sturgeon, I. Goncalves, Y. Yuan, S. M. Schoenwaelder, C. E. Wright, F. Lanza, and S. P. Jackson Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcR{gamma} deficiency Blood, June 1, 2006; 107(11): 4346 - 4353. [Abstract] [Full Text] [PDF] W. Choi, Z. A. Karim, and S. W. Whiteheart Arf6 plays an early role in platelet activation by collagen and convulxin Blood, April 15, 2006; 107(8): 3145 - 3152. [Abstract] [Full Text] [PDF] B. Bernardi, G. F. Guidetti, F. Campus, J. R. Crittenden, A. M. Graybiel, C. Balduini, and M. Torti The small GTPase Rap1b regulates the cross talk between platelet integrin {alpha}2beta1 and integrin {alpha}IIbbeta3 Blood, April 1, 2006; 107(7): 2728 - 2735. [Abstract] [Full Text] [PDF] O. Inoue, K. Suzuki-Inoue, O. J. T. McCarty, M. Moroi, Z. M. Ruggeri, T. J. Kunicki, Y. Ozaki, and S. P. Watson Laminin stimulates spreading of platelets through integrin {alpha}6beta1-dependent activation of GPVI Blood, February 15, 2006; 107(4): 1405 - 1412. [Abstract] [Full Text] [PDF] I. A. Ferreira, A. I.M. Mocking, M. A.H. Feijge, G. Gorter, T. W. van Haeften, J. W.M. Heemskerk, and J.-W. N. Akkerman Platelet Inhibition by Insulin Is Absent in Type 2 Diabetes Mellitus Arterioscler Thromb Vasc Biol, February 1, 2006; 26(2): 417 - 422. [Abstract] [Full Text] [PDF] J. Kisucka, C. E. Butterfield, D. G. Duda, S. C. Eichenberger, S. Saffaripour, J. Ware, Z. M. Ruggeri, R. K. Jain, J. Folkman, and D. D. Wagner Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage PNAS, January 24, 2006; 103(4): 855 - 860. [Abstract] [Full Text] [PDF] G. Lasser, P. Guchhait, J. L. Ellsworth, P. Sheppard, K. Lewis, P. Bishop, M. A. Cruz, J. A. Lopez, and J. Fruebis C1qTNF-related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen Blood, January 15, 2006; 107(2): 423 - 430. [Abstract] [Full Text] [PDF] I. C.A. Munnix, A. Strehl, M. J.E. Kuijpers, J. M. Auger, P. E.J. van der Meijden, M. A.M. van Zandvoort, M. G.A. oude Egbrink, B. Nieswandt, and J. W.M. Heemskerk The Glycoprotein VI-Phospholipase C{gamma}2 Signaling Pathway Controls Thrombus Formation Induced by Collagen and Tissue Factor In Vitro and In Vivo Arterioscler Thromb Vasc Biol, December 1, 2005; 25(12): 2673 - 2678. [Abstract] [Full Text] [PDF] O. J. T. McCarty, M. K. Larson, J. M. Auger, N. Kalia, B. T. Atkinson, A. C. Pearce, S. Ruf, R. B. Henderson, V. L. J. Tybulewicz, L. M. Machesky, et al. Rac1 Is Essential for Platelet Lamellipodia Formation and Aggregate Stability under Flow J. Biol. Chem., November 25, 2005; 280(47): 39474 - 39484. [Abstract] [Full Text] [PDF] A. M Carter Inflammation, thrombosis and acute coronary syndromes Diabetes and Vascular Disease Research, October 1, 2005; 2(3): 113 - 121. [Abstract] [PDF] X.-H. Leng, W. Zhang, B. Nieswandt, and P. F. Bray Effects of Estrogen Replacement Therapies on Mouse Platelet Function and Glycoprotein VI Levels Circ. Res., September 2, 2005; 97(5): 415 - 417. [Abstract] [Full Text] [PDF] K. L. Sarratt, H. Chen, M. M. Zutter, S. A. Santoro, D. A. Hammer, and M. L. Kahn GPVI and {alpha}2{beta}1 play independent critical roles during platelet adhesion and aggregate formation to collagen under flow Blood, August 15, 2005; 106(4): 1268 - 1277. [Abstract] [Full Text] [PDF] T. Renne, M. Pozgajova, S. Gruner, K. Schuh, H.-U. Pauer, P. Burfeind, D. Gailani, and B. Nieswandt Defective thrombus formation in mice lacking coagulation factor XII J. Exp. Med., July 18, 2005; 202(2): 271 - 281. [Abstract] [Full Text] [PDF] A. Mazharian, S. Roger, P. Maurice, E. Berrou, M. R. Popoff, M. F. Hoylaerts, F. Fauvel-Lafeve, A. Bonnefoy, and M. Bryckaert Differential Involvement of ERK2 and p38 in Platelet Adhesion to Collagen J. Biol. Chem., July 15, 2005; 280(28): 26002 - 26010. [Abstract] [Full Text] [PDF] Y. Sato, H. Fujiwara, B.-X. Zeng, T. Higuchi, S. Yoshioka, and S. Fujii Platelet-derived soluble factors induce human extravillous trophoblast migration and differentiation: platelets are a possible regulator of trophoblast infiltration into maternal spiral arteries Blood, July 15, 2005; 106(2): 428 - 435. [Abstract] [Full Text] [PDF] J. F.W. Keuren, S. J.H. Wielders, H. Ulrichts, T. Hackeng, J. W.M. Heemskerk, H. Deckmyn, E. M. Bevers, and T. Lindhout Synergistic Effect of Thrombin on Collagen-Induced Platelet Procoagulant Activity Is Mediated Through Protease-Activated Receptor-1 Arterioscler Thromb Vasc Biol, July 1, 2005; 25(7): 1499 - 1505. [Abstract] [Full Text] [PDF] C. Nonne, N. Lenain, B. Hechler, P. Mangin, J.-P. Cazenave, C. Gachet, and F. Lanza Importance of Platelet Phospholipase C{gamma}2 Signaling in Arterial Thrombosis as a Function of Lesion Severity Arterioscler Thromb Vasc Biol, June 1, 2005; 25(6): 1293 - 1298. [Abstract] [Full Text] [PDF] T. Rabie, A. Strehl, A. Ludwig, and B. Nieswandt Evidence for a Role of ADAM17 (TACE) in the Regulation of Platelet Glycoprotein V J. Biol. Chem., April 15, 2005; 280(15): 14462 - 14468. [Abstract] [Full Text] [PDF] C. L. Kempton, M. Hoffman, H. R. Roberts, and D. M. Monroe Platelet Heterogeneity: Variation in Coagulation Complexes on Platelet Subpopulations Arterioscler Thromb Vasc Biol, April 1, 2005; 25(4): 861 - 866. [Abstract] [Full Text] [PDF] S. Gruner, M. Prostredna, M. Koch, Y. Miura, V. Schulte, S. M. Jung, M. Moroi, and B. Nieswandt Relative antithrombotic effect of soluble GPVI dimer compared with anti-GPVI antibodies in mice Blood, February 15, 2005; 105(4): 1492 - 1499. [Abstract] [Full Text] [PDF] P. A. Jordan, J. M. Stevens, G. P. Hubbard, N. E. Barrett, T. Sage, K. S. Authi, and J. M. Gibbins A role for the thiol isomerase protein ERP5 in platelet function Blood, February 15, 2005; 105(4): 1500 - 1507. [Abstract] [Full Text] [PDF] G. Stephens, Y. Yan, M. Jandrot-Perrus, J.-L. Villeval, K. J. Clemetson, and D. R. Phillips Platelet activation induces metalloproteinase-dependent GP VI cleavage to down-regulate platelet reactivity to collagen Blood, January 1, 2005; 105(1): 186 - 191. [Abstract] [Full Text] [PDF] C. Lecut, V. Arocas, H. Ulrichts, A. Elbaz, J.-L. Villeval, J.-J. Lacapere, H. Deckmyn, and M. Jandrot-Perrus Identification of Residues within Human Glycoprotein VI Involved in the Binding to Collagen: EVIDENCE FOR THE EXISTENCE OF DISTINCT BINDING SITES J. Biol. Chem., December 10, 2004; 279(50): 52293 - 52299. [Abstract] [Full Text] [PDF] E. E. Gardiner, J. F. Arthur, M. L. Kahn, M. C. Berndt, and R. K. Andrews Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinase Blood, December 1, 2004; 104(12): 3611 - 3617. [Abstract] [Full Text] [PDF] S. Sabri, M. Jandrot-Perrus, J. Bertoglio, R. W. Farndale, V. M.-D. Mas, N. Debili, and W. Vainchenker Differential regulation of actin stress fiber assembly and proplatelet formation by {alpha}2{beta}1 integrin and GPVI in human megakaryocytes Blood, November 15, 2004; 104(10): 3117 - 3125. [Abstract] [Full Text] [PDF] S. Gruner, M. Prostredna, B. Aktas, A. Moers, V. Schulte, T. Krieg, S. Offermanns, B. Eckes, and B. Nieswandt Anti-Glycoprotein VI Treatment Severely Compromises Hemostasis in Mice With Reduced {alpha}2{beta}1 Levels or Concomitant Aspirin Therapy Circulation, November 2, 2004; 110(18): 2946 - 2951. [Abstract] [Full Text] [PDF] A. Moers, N. Wettschureck, S. Gruner, B. Nieswandt, and S. Offermanns Unresponsiveness of Platelets Lacking Both G{alpha}q and G{alpha}13: IMPLICATIONS FOR COLLAGEN-INDUCED PLATELET ACTIVATION J. Biol. Chem., October 29, 2004; 279(44): 45354 - 45359. [Abstract] [Full Text] [PDF] S. J. Shattil and P. J. Newman Integrins: dynamic scaffolds for adhesion and signaling in platelets Blood, September 15, 2004; 104(6): 1606 - 1615. [Abstract] [Full Text] [PDF] P. MAURICE, C. LEGRAND, and F. FAUVEL-LAFEVE Platelet adhesion and signaling induced by the octapeptide primary binding sequence (KOGEOGPK) from type III collagen FASEB J, September 1, 2004; 18(12): 1339 - 1347. [Abstract] [Full Text] [PDF] C. Lecut, A. Schoolmeester, M. J.E. Kuijpers, J. L.V. Broers, M. A.M.J. van Zandvoort, K. Vanhoorelbeke, H. Deckmyn, M. Jandrot-Perrus, and J. W.M. Heemskerk Principal Role of Glycoprotein VI in {alpha}2{beta}1 and {alpha}IIb{beta}3 Activation During Collagen-Induced Thrombus Formation Arterioscler Thromb Vasc Biol, September 1, 2004; 24(9): 1727 - 1733. [Abstract] [Full Text] [PDF] B. Boylan, H. Chen, V. Rathore, C. Paddock, M. Salacz, K. D. Friedman, B. R. Curtis, M. Stapleton, D. K. Newman, M. L. Kahn, et al. Anti-GPVI-associated ITP: an acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcR{gamma}-chain complex from the human platelet surface Blood, September 1, 2004; 104(5): 1350 - 1355. [Abstract] [Full Text] [PDF] N. Cabeza, Z. Li, C. Schulz, E. Kremmer, S. Massberg, A. Bultmann, and M. Gawaz Surface Expression of Collagen Receptor Fc Receptor-{gamma}/Glycoprotein VI Is Enhanced on Platelets in Type 2 Diabetes and Mediates Release of CD40 Ligand and Activation of Endothelial Cells Diabetes, August 1, 2004; 53(8): 2117 - 2121. [Abstract] [Full Text] [PDF] J. M. Gibbins Platelet adhesion signalling and the regulation of thrombus formation J. Cell Sci., July 15, 2004; 117(16): 3415 - 3425. [Abstract] [Full Text] [PDF] M. J. E. Kuijpers, V. Schulte, C. Oury, T. Lindhout, J. Broers, M. F. Hoylaerts, B. Nieswandt, and J. W. M. Heemskerk Facilitating roles of murine platelet glycoprotein Ib and {alpha}IIb{beta}3 in phosphatidylserine exposure during vWF-collagen-induced thrombus formation J. Physiol., July 15, 2004; 558(2): 403 - 415. [Abstract] [Full Text] [PDF]

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