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Prepublished online as a Blood First Edition Paper on March 13, 2003; DOI 10.1182/blood-2003-01-0025. This Article Full Text (PDF) All Versions of this Article: 2003-01-0025v1 102/1/83    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cortes, J. Articles by Kantarjian, H. Search for Related Content PubMed PubMed Citation Articles by Cortes, J. Articles by Kantarjian, H. Social Bookmarking                   What's this? Submitted January 6, 2003 Accepted February 27, 2003 Result of high-dose imatinib mesylate in patients with Philadelphia chromosome-positive chronic myeloid leukemia after failure of interferon- Jorge Cortes*, Francis Giles, Susan O'Brien, Deborah Thomas, Guillermo Garcia-Manero, Mary Beth Rios, Stefan Faderl, Srdan Verstovsek, Alessandra Ferrajoli, Emil J Freireich, Moshe Talpaz, and Hagop Kantarjian Department of Leukemia, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA Department of Bioimmunotherapy, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA * Corresponding author; email: jcortes{at}mdanderson.org. Imatinib (Gleevec) at 400 mg daily is effective in chronic phase CML post interferon failure, although only a few patients achieve a molecular remission. We investigated whether higher doses of imatinib may be more effective. Thirty-six patients with chronic phase CML failure to interferon were treated with imatinib 400 mg twice daily. Median time from diagnosis was 25 months (range, 10 to 135); 4 patients (11%) had clonal evolution. All 11 patients with active disease achieved complete hematologic response. Excluding patients with <35% Ph-positive metaphases before the start of therapy, 19/21 (90%) evaluable patients achieved a major cytogenetic response. Twenty-four of 27 (89%) evaluable patients achieved a complete cytogenetic response. Quantitative PCR was performed in bone marrow every 3 months. Eighteen of 32 evaluable patients (56%) showed BCR-ABL/ABL percentage ratios <0.045%, including 13 (41%) with undetectable levels. With a median follow-up of 15 months, all patients were alive in chronic phase. Toxicities were similar to those reported with standard dose; 71% of patients continue to receive 600 mg of imatinib daily. In conclusion, high-dose imatinib induces complete cytogenetic responses in most patients with chronic phase CML post interferon failure. 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