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Prepublished online as a Blood First Edition Paper on February 20, 2003; DOI 10.1182/blood-2003-01-0081. This Article Full Text (PDF) All Versions of this Article: 2003-01-0081v1 101/12/4714    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cortes, J. Articles by Kantarjian, H. Search for Related Content PubMed PubMed Citation Articles by Cortes, J. Articles by Kantarjian, H. Social Bookmarking                   What's this? Submitted January 10, 2003 Accepted February 8, 2003 Efficacy of imatinib mesylate in the treatment of idiopathic hypereosinophilic syndrome Jorge Cortes*, Patricia Ault, Charles Koller, Deborah Thomas, Alessandra Ferrajoli, William Wierda, Mary B Rios, Laurie Letvak, Elizabeth S Kaled, and Hagop Kantarjian Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX, USA Novartis Pharmaceuticals Corp, East Hanover, NJ, USA * Corresponding author; email: jcortes{at}mdanderson.org. Idiopathic hypereosinophilic syndrome (HES) is a myeloproliferative disorder characterized by persistent eosinophilia and organ involvement. Different treatments have been investigated in HES with modest success. Imatinib has been suggested to be active in HES. We treated 9 patients with HES with imatinib 100 mg daily. Those without response after 4 weeks had their dose increased to 400 mg daily. Seven had failed prior therapies. Five patients responded: 4 had a sustained complete remission lasting a median of 12+ weeks (range, 9+ to 36+ weeks), and 1 had a transient response. One patient died in complete remission. Responses occurred within 4 weeks of therapy; only one responder required an increase in dose to 400 mg daily. Three of four non-responders failed to respond to an increase in dose. Toxicity was minimal. We conclude that imatinib is effective in HES. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Verstovsek, A. Tefferi, J. Cortes, S. O'Brien, G. Garcia-Manero, A. Pardanani, C. Akin, S. Faderl, T. Manshouri, D. Thomas, et al. Phase II Study of Dasatinib in Philadelphia Chromosome-Negative Acute and Chronic Myeloid Diseases, Including Systemic Mastocytosis Clin. Cancer Res., June 15, 2008; 14(12): 3906 - 3915. [Abstract] [Full Text] [PDF] M. Baccarani, D. Cilloni, M. Rondoni, E. Ottaviani, F. Messa, S. Merante, M. 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