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Prepublished online as a Blood First Edition Paper on May 1, 2003; DOI 10.1182/blood-2003-01-0221.
Submitted January 28, 2003
Accepted April 21, 2003
Increased apoptosis in bone marrow B lymphocytes but not T lymphocytes in myelodysplastic syndrome
Hesham M Amin, Iman Jilani, Elihu H Estey, Michael J Keating, Amanda L Dey, Taghi Manshouri, Hagop M Kantarjian, Zeev Estrov, Jorge E Cortes, Deborah A Thomas, Francis J Giles, and Maher Albitar*
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Department of Leukemia, The University of Texas MD Annderson Cancer Center, Houston, TX, USA
* Corresponding author; email: malbitar{at}mdanderson.org.
The hallmark of myelodysplastic syndrome (MDS) is enhanced apoptosis in myeloid, erythroid, and megakaryocytic cells in the bone marrow leading to ineffective hematopoiesis. Recent studies suggested that immunological and microenvironmental factors play a role in the pathophysiology of this disease. We report a significant increase in apoptosis in bone marrow B-lymphocytes in MDS as compared to that found in acute myeloid leukemia and normal controls. Furthermore, we demonstrate that patients with refractory anemia with excess blasts in transformation (RAEB-T) had apoptosis levels in lymphocytes similar to those seen in other subtypes of MDS. Our findings suggest that the alterations in B-lymphocytes in the form of increased apoptosis can be seen in MDS and support the concept that immune modulation plays a role in the pathophysiology of MDS.
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