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Prepublished online as a Blood First Edition Paper on May 22, 2003; DOI 10.1182/blood-2003-01-0232.
Submitted January 27, 2003
Accepted May 8, 2003
IL-15 drives neonatal T cells to acquire CD56 and become activated effector cells
Sharon Cookson* and Denis J Reen
Children's Research Centre, Our Lady's Hospital for Sick Children, Dublin, Ireland
Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland
* Corresponding author; email: sharon.cookson{at}ucd.ie.
Expression of one or more NK receptors on T cells may correlate with effector function. This study investigated the frequency of neonatal NK receptor-positive (NKR+) T cells and their expansionary properties with IL-2, IL-7 or IL-15. Whilst cord blood contains significantly decreased frequencies of NKR+ T cells compared to adult blood, newborn CD56+CD3+ cells could be expanded 200-fold during culture with IL-15. By depleting CD56+ cells, we were able to determine that this expansion was due to a subpopulation of T cells acquiring CD56 expression. Moreover, CD56 acquisition was associated with a distinct CD8+CD25+IFN- + phenotype. This property could therefore be exploited during bone marrow reconstitution and may partially account for the resilience of the newborn to infection.
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