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Prepublished online as a Blood First Edition Paper on May 8, 2003; DOI 10.1182/blood-2003-01-0287. This Article Full Text (PDF) All Versions of this Article: 2003-01-0287v1 102/5/1606    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Press, O. W Articles by Fisher, R. I Search for Related Content PubMed PubMed Citation Articles by Press, O. W Articles by Fisher, R. I Social Bookmarking                   What's this? Submitted February 5, 2003 Accepted April 25, 2003 A Phase II Trial of CHOP chemotherapy followed by tositumomab/iodine I 131 tositumomab for previously untreated follicular non-Hodgkin's lymphoma: Southwest Oncology Group protocol S9911 Oliver W Press*, Joseph M Unger, Rita M Braziel, David G Maloney, Thomas P Miller, Michael LeBlanc, Ellen R Gaynor, Saul E Rivkin, and Richard I Fisher Fred Hutchinson Cancer Research Center, Seattle, WA, USA Southwest Oncology Group Statistical Center, Seattle, WA, USA Oregon Health Sciences University, Portland, OR, USA Arizona Cancer Center, University of Arizona, Tucson, AZ, USA Loyola University Stritch School of Medicine, Maywood, IL, USA Puget Sound Oncology Consortium, Seattle, WA, USA James P. Wilmot Cancer Center, University of Rochester Medical Center, Rochester, NY, USA * Corresponding author; email: press{at}u.washington.edu. Advanced follicular lymphoma is incurable with conventional chemotherapy and radiotherapy. The Southwest Oncology Group conducted a Phase II trial (S9911) of a novel regimen consisting of six cycles of CHOP chemotherapy followed 4-8 weeks later by tositumomab/iodine I 131 tositumomab (anti-CD20 antibody) in 90 eligible patients with previously untreated, advanced stage follicular lymphoma. Treatment was well tolerated. Reversible myelosuppression was the main adverse event and was more severe during CHOP chemotherapy than following radioimmunotherapy. The overall response rate to the entire treatment regimen was 90%, including 67% complete remissions (CR + CRu) and 23% partial remissions (PR). Twenty-seven of the 47 (57%) fully evaluable patients who achieved less than a CR with CHOP improved their remission status after tositumomab/iodine I 131 tositumomab. With a median follow-up of 2.3 years, the 2 year progression-free survival (PFS) was estimated to be 81%, with a two year overall survival of 97%. This study has established the feasibility, tolerability, and efficacy of this regimen for patients with advanced follicular lymphoma. This novel treatment appears promising compared to SWOG's historical experience using CHOP alone and is currently being compared to CHOP plus rituximab in a randomized Phase III trial (S0016). CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. W. Sweetenham, B. Goldman, M. L. LeBlanc, J. R. Cook, R. R. Tubbs, O. W. Press, D. G. Maloney, R. I. Fisher, L. M. Rimsza, R. M. Braziel, et al. Prognostic value of regulatory T cells, lymphoma-associated macrophages, and MUM-1 expression in follicular lymphoma treated before and after the introduction of monoclonal antibody therapy: a Southwest Oncology Group Study Ann. Onc., October 29, 2009; (2009) mdp460v1. [Abstract] [Full Text] [PDF] S. A. Gregory, K. Hohloch, C. Gisselbrecht, K. Tobinai, and M. 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