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Prepublished online as a Blood First Edition Paper on July 17, 2003; DOI 10.1182/blood-2003-01-0320. This Article Full Text (PDF) All Versions of this Article: 2003-01-0320v1 102/10/3504    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gris, J.-C. Articles by Dauzat, M. Search for Related Content PubMed PubMed Citation Articles by Gris, J.-C. Articles by Dauzat, M. Social Bookmarking                   What's this? Submitted February 3, 2003 Accepted July 7, 2003 Antiphospholipid/antiprotein antibodies, hemostasis-related autoantibodies, and plasma homocysteine as risk factors for a first early pregnancy loss: a matched case-control study Jean-Christophe Gris*, Thomas V Perneger, Isabelle Quere, Eric Mercier, Pascale Fabbro-Peray, Geraldine Lavigne-Lissalde, Mederic Hoffet, Herve Dechaud, Jean-Christophe Boyer, Sylvie Ripart-Neveu, Marie-Laure Tailland, Jean-Pierre Daures, Pierre Mares, and Michel Dauzat Haematology Laboratory, University Hospital, Nimes, France; Montpellier 1 University, Nimes, France Department of Medical Information, University Hospital, Nimes, France Department of Gynaecology and Obstetrics, University Hospital, Nimes, France Quality of Care Unit, Geneva University Hospitals, Geneva, Switzerland * Corresponding author; email: jcgris{at}chu-nimes.fr. Maternal hypercoagulability is a possible cause of miscarriage during the 8th and 9th week of pregnancy, when the placenta replaces the yolk sac. We thus examined associations between putative markers of an acquired hypercoagulable state and the risk of first miscarriage. We conducted a case-control study comparing 743 women who miscarried in weeks 8 and 9 with 743 women who underwent a first provoked abortion, matched for age, number of pregnancies and time elapsed since abortion. Levels of plasma homocysteine and of various antiphospholipid/antiprotein and hemostasis-related autoantibodies were categorized in four strata (percentiles 1-80, 81-95, 96-99, 100 among controls) and analyzed in conditional logistic regression models. Pregnancy loss was independently associated with positive lupus anticoagulant (matched odds ratio (OR) 2.6, 95% confidence interval (CI) 1.1-6.0), high levels of IgM antibodies against cardiolipin (OR for percentile 100 versus 0-80: 3.5, CI 1.2-10.1) and against phosphatidylethanolamine (OR 4.7, CI 1.9-12.1), high levels of IgG antibodies against annexin V (OR 3.2, CI 1.1-9.1) and against tissue-type plasminogen activator (OR 19.5, CI 7.9-48.0), and high homocysteinaemia (OR 4.1, CI 1.3-12.5). A first early pregnancy loss is associated with increased levels of several autoantibodies and of homocysteine. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Forges, P. Monnier-Barbarino, J.M. Alberto, R.M. Gueant-Rodriguez, J.L. Daval, and J.L. Gueant Impact of folate and homocysteine metabolism on human reproductive health Hum. Reprod. Update, May 1, 2007; 13(3): 225 - 238. [Abstract] [Full Text] [PDF] W. Zammiti, N. Mtiraoui, C. Kallel, E. Mercier, W. Y Almawi, and T. Mahjoub A case-control study on the association of idiopathic recurrent pregnancy loss with autoantibodies against {beta}2-glycoprotein I and annexin V. Reproduction, April 1, 2006; 131(4): 817 - 822. [Abstract] [Full Text] [PDF] P. L. Bockenstedt Management of Hereditary Hypercoagulable Disorders Hematology, January 1, 2006; 2006(1): 444 - 449. [Abstract] [Full Text] [PDF] K. A Bartley, B. A Underwood, and R. J Deckelbaum A life cycle micronutrient perspective for women's health Am. J. Clinical Nutrition, May 1, 2005; 81(5): 1188S - 1193S. [Abstract] [Full Text] [PDF] G Triolo, A Ferrante, A Accardo-Palumbo, F Ciccia, M Cadelo, A Castelli, A Perino, and G Licata IVIG in APS pregnancy Lupus, September 1, 2004; 13(9): 731 - 735. [Abstract] [PDF] V. Hurtado, R. Montes, J.-C. Gris, M. L. Bertolaccini, A. Alonso, M. A. Martinez-Gonzalez, M. A. Khamashta, K. Fukudome, D. A. Lane, and J. Hermida Autoantibodies against EPCR are found in antiphospholipid syndrome and are a risk factor for fetal death Blood, September 1, 2004; 104(5): 1369 - 1374. [Abstract] [Full Text] [PDF] J.-C. Gris, E. Mercier, I. Quere, G. Lavigne-Lissalde, E. Cochery-Nouvellon, M. Hoffet, S. Ripart-Neveu, M.-L. Tailland, M. Dauzat, and P. Mares Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder Blood, May 15, 2004; 103(10): 3695 - 3699. [Abstract] [Full Text] [PDF]

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