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Prepublished online as a Blood First Edition Paper on April 24, 2003; DOI 10.1182/blood-2003-01-0334. This Article Full Text (PDF) All Versions of this Article: 2003-01-0334v1 102/4/1155    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Xiong, J.-P. Articles by Arnaout, M A. Search for Related Content PubMed PubMed Citation Articles by Xiong, J.-P. Articles by Arnaout, M A. Social Bookmarking                   What's this? Submitted February 19, 2003 Accepted April 9, 2003 New insights into the structural basis of integrin activation Jian-Ping Xiong, Thilo Stehle, Simon L Goodman, and M Amin Arnaout* Department of Medicine, Massachusetts General Hospital, Charlestown, MA, USA; Department of Medicine, Massachusetts General Hospital, Charlestown, MA, USA Department of Oncology Research, Merck KGaA, Darmstadt, Germany Department of Medicine, Massachusetts General Hospital, Charlestown, MA, USA * Corresponding author; email: arnaout{at}receptor.mgh.harvard.edu. Integrins are cell adhesion receptors that communicate biochemical and mechanical signals in a bidirectional manner across the plasma membrane and thus influence most cellular functions. Intracellular signals switch integrins into a ligand-competent state as a result of elicited conformational changes in the integrin ectodomain. Binding of extracellular ligands induces in turn structural changes that convey distinct signals to the cell interior. The structural basis of this bidirectional signaling has been the focus of intensive study for the past three decades. In this perspective, we develop a new hypothesis for integrin activation based on recent crystallographic, electron microscopy and biochemical studies. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J.-P. Xiong, B. Mahalingham, J. L. Alonso, L. A. Borrelli, X. Rui, S. Anand, B. T. Hyman, T. Rysiok, D. Muller-Pompalla, S. L. Goodman, et al. Crystal structure of the complete integrin {alpha}V{beta}3 ectodomain plus an {alpha}/{beta} transmembrane fragment J. Cell Biol., August 24, 2009; 186(4): 589 - 600. [Abstract] [Full Text] [PDF] M. Moser, K. R. Legate, R. Zent, and R. Fassler The Tail of Integrins, Talin, and Kindlins Science, May 15, 2009; 324(5929): 895 - 899. [Abstract] [Full Text] [PDF] J. Liu, P. B. Gurpur, and S. J. 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