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Prepublished online as a Blood First Edition Paper on July 17, 2003; DOI 10.1182/blood-2003-02-0384. This Article Full Text (PDF) All Versions of this Article: 2003-02-0384v1 102/9/3302    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Palucka, A K. Articles by Banchereau, J. Search for Related Content PubMed PubMed Citation Articles by Palucka, A K. Articles by Banchereau, J. Social Bookmarking                   What's this? Submitted February 6, 2003 Accepted July 3, 2003 Human dendritic cell subsets in NOD/SCID mice engrafted with CD34+ hematopoietic progenitors A Karolina Palucka*, Joel Gatlin, Jean Philippe Blanck, Michael W Melkus, Sandra Clayton, Hideki Ueno, Elizabeth T Kraus, Petra Cravens, Lynda Bennett, Angela Padgett-Thomas, Florentina Marches, Miguel Islas-Ohlmayer, J Victor Garcia, and Jacques Banchereau Baylor Institute for Immunology Research, Dallas, TX, USA The University of Texas Southwestern Medical Center, Dallas, TX, USA * Corresponding author; email: karolinp{at}baylorhealth.edu. Distinct human dendritic cell subsets differentially control immunity. Thus, insights into their in vivo functions are important to understand the launching and modulation of immune responses. We show that NOD/SCID mice engrafted with human CD34+ hematopoietic progenitors develop human myeloid and plasmacytoid DCs. Skin display immature DCs expressing Langerin while other tissues display interstitial DCs. Myeloid DCs from these mice induce proliferation of allogeneic CD4 T cells in vitro, and bone marrow human cells containing plasmacytoid DCs release IFN- upon influenza virus exposure. Injection of influenza virus into reconstituted mice triggers IFN- release and maturation of mDCs. Thus, these mice provide a model to study the pathophysiology of human DC subsets. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Kwant-Mitchell, A. A. Ashkar, and K. L. Rosenthal Mucosal Innate and Adaptive Immune Responses against Herpes Simplex Virus Type 2 in a Humanized Mouse Model J. Virol., October 15, 2009; 83(20): 10664 - 10676. [Abstract] [Full Text] [PDF] C. I. Yu, M. Gallegos, F. Marches, G. Zurawski, O. Ramilo, A. Garcia-Sastre, J. Banchereau, and A. K. Palucka Broad influenza-specific CD8+ T-cell responses in humanized mice vaccinated with influenza virus vaccines Blood, November 1, 2008; 112(9): 3671 - 3678. [Abstract] [Full Text] [PDF] F. Ishikawa, H. Niiro, T. Iino, S. Yoshida, N. Saito, S. Onohara, T. Miyamoto, H. Minagawa, S.-i. Fujii, L. D. Shultz, et al. The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways Blood, November 15, 2007; 110(10): 3591 - 3660. [Abstract] [Full Text] [PDF] C. Aspord, A. Pedroza-Gonzalez, M. Gallegos, S. Tindle, E. C. Burton, D. Su, F. Marches, J. Banchereau, and A. K. Palucka Breast cancer instructs dendritic cells to prime interleukin 13-secreting CD4+ T cells that facilitate tumor development J. Exp. Med., May 14, 2007; 204(5): 1037 - 1047. [Abstract] [Full Text] [PDF] J. Abbasian, D. Mahmud, N. Mahmud, S. Chunduri, H. Araki, P. Reddy, R. Hoffman, M. Arpinati, J. L. M. Ferrara, and D. Rondelli Allogeneic T cells induce rapid CD34+ cell differentiation into CD11c+CD86+ cells with direct and indirect antigen-presenting function Blood, July 1, 2006; 108(1): 203 - 208. [Abstract] [Full Text] [PDF] F. Macchiarini, M. G. Manz, A. K. Palucka, and L. D. Shultz Humanized mice: are we there yet? J. Exp. Med., November 21, 2005; 202(10): 1307 - 1311. [Abstract] [Full Text] [PDF] D. A. Bente, M. W. Melkus, J. V. Garcia, and R. Rico-Hesse Dengue Fever in Humanized NOD/SCID Mice J. Virol., November 1, 2005; 79(21): 13797 - 13799. [Abstract] [Full Text] [PDF] E. Traggiai, L. Chicha, L. Mazzucchelli, L. Bronz, J.-C. Piffaretti, A. Lanzavecchia, and M. G. Manz Development of a Human Adaptive Immune System in Cord Blood Cell-Transplanted Mice Science, April 2, 2004; 304(5667): 104 - 107. [Abstract] [Full Text] [PDF] D.-W. Kim, Y.-J. Chung, T.-G. Kim, Y.-L. Kim, and I.-H. Oh Cotransplantation of third-party mesenchymal stromal cells can alleviate single-donor predominance and increase engraftment from double cord transplantation Blood, March 1, 2004; 103(5): 1941 - 1948. [Abstract] [Full Text] [PDF]

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