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Prepublished online as a Blood First Edition Paper on April 24, 2003; DOI 10.1182/blood-2003-02-0443. This Article Full Text (PDF) All Versions of this Article: 2003-02-0443v1 102/4/1363    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Martinelli, I. Articles by Mannucci, P. M. Search for Related Content PubMed PubMed Citation Articles by Martinelli, I. Articles by Mannucci, P. M. Social Bookmarking                   What's this? Submitted February 20, 2003 Accepted April 11, 2003 Hyperhomocysteinemia in cerebral vein thrombosis Ida Martinelli*, Tullia Battaglioli, Paola Pedotti, Marco Cattaneo, and Pier Mannuccio Mannucci Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Department of Internal Medicine, IRCCS Maggiore Hospital and University of Milano, Milan, Italy Molecular and Genetic Epidemiology Unit, IRCCS Maggiore Hospital and University of Milano, Milan, Italy Unit of Hematology and Thrombosis, Department of Medicine, Surgery and Dentistry, Ospedale San Paolo, University of Milano, Milan, Italy * Corresponding author; email: martin{at}policlinico.mi.it. High plasma levels of total homocysteine (tHcy) are a risk factor for deep vein thrombosis. Because no information on the relationship between cerebral vein thrombosis and hyperhomocysteinemia is available, a case-control study of 121 patients with a first episode of cerebral vein thrombosis and 242 healthy controls was carried out. Fasting plasma levels of tHcy and their post-methionine load (PML) increments, together with other laboratory markers of thrombophilia, were measured in plasma or DNA. Hyperhomocysteinemia (high fasting tHcy and/or PML increments) was diagnosed in 33 patients (27%) and 20 controls (8%) (odds ratio of 4.2, 95% CI 2.3-7.6). Low levels of serum folate and the 677TT methylene tetrahydrofolate reductase were associated with hyperhomocysteinemia, but in a multivariate model hyperhomocysteinemia only was associated with an increased risk for cerebral vein thrombosis. Oral contraceptive intake was associated with the disease with an odds ratio of 6.1 (95% CI 3.3-11.0). The combined presence of the latter and hyperhomocysteinemia increased the risk of the disease with an odds ratio of 19.5 (95% CI 5.7-67.3). In conclusion, hyperhomocysteinemia is associated with a 4-fold increased risk of cerebral vein thrombosis; whether or not its correction with vitamins reduces the risk of the disease remains to be demonstrated. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: I. Martinelli, M. Franchini, and P. M. Mannucci How I treat rare venous thromboses Blood, December 15, 2008; 112(13): 4818 - 4823. [Abstract] [Full Text] [PDF] B. A. Khealani, M. Wasay, M. Saadah, E. Sultana, S. Mustafa, F. S. Khan, and A. K. Kamal Cerebral Venous Thrombosis: A Descriptive Multicenter Study of Patients in Pakistan and Middle East Stroke, October 1, 2008; 39(10): 2707 - 2711. [Abstract] [Full Text] [PDF] E. S. Roach, M. R. Golomb, R. Adams, J. Biller, S. Daniels, G. deVeber, D. Ferriero, B. V. Jones, F. J. Kirkham, R. M. Scott, et al. 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