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Prepublished online as a Blood First Edition Paper on May 1, 2003; DOI 10.1182/blood-2003-02-0517. This Article Full Text (PDF) All Versions of this Article: 2003-02-0517v1 102/5/1569    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hanna, J. Articles by Mandelboim, O. Search for Related Content PubMed PubMed Citation Articles by Hanna, J. Articles by Mandelboim, O. Related Collections Related Article in Blood Online Social Bookmarking                   What's this? Submitted February 19, 2003 Accepted April 24, 2003 CXCL12 expression by invasive trophoblasts induces the specific migration of CD16 negative human natural killer cells Jacob Hanna, Ori Wald, Debra Goldman-Wohl, Diana Prus, Gal Markel, Roi Gazit, Gil Katz, Ronit Haimov-Kochman, Nobutaka Fujii, Simcha Yagel, Amnon Peled, and Ofer Mandelboim* Lautenberg Center for General and Tumor Immunology, Hebrew University, Jerusalem, Israel Goldyne Savad Institue of Gene Therapy, Hadassah University Hospital, Jerusalem, Israel The Department of Obstetrics and Gynecology, Hadassah University Hospital- Mount Scopus, Jerusalem, Israel The Department of Pathology, Hadassah University Hospital- Mount Scopus, Jerusalem, Israel Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan * Corresponding author; email: oferman{at}md2.huji.ac.il. In the decidua maternal Natural Killer (NK) cells, characterized by lack of CD16, are found in direct contact with the fetal extravillous trophoblasts (EVT). It is yet unknown which factors contribute to the specific homing of this unique NK subset to the decidua. In this study we analyze the chemokine receptor repertoire on various NK populations derived from the peripheral blood and decidua. We show that CXCR4 and CXCR3 receptors are preferentially expressed on CD16 negative NK subsets derived either from the peripheral blood or the decidua and that these receptors are involved in migration of all NK subsets to their ligands. We further demonstrate in vivo that invading EVT, that eventually perform endovascular invasion express CXCL12, the ligand for CXCR4, but not ligands for CXCR3. Indeed, specific accumulation of the CD16 negative NK cells at the expense of CD16 positive cells was only observed when in vitro migration was performed with ligands for CXCR4. Finally, incubation of the peripheral blood CD16 negative NK cells with cytokines present in the decidua, especially IL-15, resulted in the expression of chemokine receptor repertoire similar to that observed on decidual NK cells, suggesting an additional important regulatory effect of local decidual cytokines. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Extending a welcome into the uterine bed... B. Anne Croy Blood 2003 102: 1561. [Full Text] [PDF] This article has been cited by other articles: T. V. Mallidi, L. E. Craig, S. R. Schloemann, and J. K. Riley Murine Endometrial and Decidual NK1.1+ Natural Killer Cells Display a B220+CD11c+ Cell Surface Phenotype Biol Reprod, August 1, 2009; 81(2): 310 - 318. [Abstract] [Full Text] [PDF] P. C. Cavanagh, C. Dunk, M. Pampillo, J. M. Szereszewski, J. E. Taylor, C. Kahiri, V. Han, S. Lye, M. Bhattacharya, and A. V. 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