SEARCH:   Advanced

Prepublished online as a Blood First Edition Paper on May 8, 2003; DOI 10.1182/blood-2003-02-0578. This Article Full Text (PDF) Supplemental Tables and Figures All Versions of this Article: 2003-02-0578v1 102/5/1849    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Yagi, T. Articles by Ichikawa, H. Search for Related Content PubMed PubMed Citation Articles by Yagi, T. Articles by Ichikawa, H. Social Bookmarking                   What's this? Submitted February 21, 2003 Accepted April 28, 2003 Identification of a gene expression signature associated with prognosis of pediatric AML Tomohito Yagi, Akira Morimoto, Mariko Eguchi, Shigeyoshi Hibi, Masahiro Sako, Eiichi Ishii, Shuki Mizutani, Shinsaku Imashuku, Misao Ohki, and Hitoshi Ichikawa* Cancer Genomics Division, National Cancer Center Research Institute, Tokyo, Japan; Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan Chester Beatty Laboratories, Leukaemia Research Fund Centre, London, United Kingdom Division of Pediatrics, Osaka City General Hospital, Osaka, Japan Department of Pediatrics, Saga Medical School, Saga, Japan Department of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan Kyoto City Institute of Health and Environmental Sciences, Kyoto, Japan Cancer Genomics Division, National Cancer Center Research Institute, Tokyo, Japan * Corresponding author; email: hichikaw{at}ncc.go.jp. Most patients with acute myeloid leukemia (AML) enter complete remission (CR) after treatment with chemotherapy, but a large number of them relapse with resistant disease. To identify genes that are associated with their prognosis, we analyzed the gene expression of 54 pediatric patients with AML using an oligonucleotide microarray that contains 12,566 probe sets. A supervised approach using the Student's t-test selected a prognostic set of 35 genes, some of which are associated with regulation of cell cycle and apoptosis. Most of these genes had not previously been reported to be associated with prognosis, and were not correlated with morphologically classified French-American-British (FAB) subtypes or with karyotypes. These results indicate the existence of prognosis-associated genes, which are independent of cell lineage and cytogenetic abnormalities, and can provide therapeutic direction for individual risk-adapted therapy for pediatric AML patients. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: B. J. Wouters, B. Lowenberg, and R. Delwel A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects Blood, January 8, 2009; 113(2): 291 - 298. [Abstract] [Full Text] [PDF] S. Meshinchi and R. J. Arceci Prognostic Factors and Risk-Based Therapy in Pediatric Acute Myeloid Leukemia Oncologist, March 1, 2007; 12(3): 341 - 355. [Abstract] [Full Text] [PDF] M. Wunderlich, O. Krejci, J. Wei, and J. C. Mulloy Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability Blood, September 1, 2006; 108(5): 1690 - 1697. [Abstract] [Full Text] [PDF] C. S. Wilson, G. S. Davidson, S. B. Martin, E. Andries, J. Potter, R. Harvey, K. Ar, Y. Xu, K. J. Kopecky, D. P. Ankerst, et al. Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction Blood, July 15, 2006; 108(2): 685 - 696. [Abstract] [Full Text] [PDF] A. Andersson, T. Olofsson, D. Lindgren, B. Nilsson, C. Ritz, P. Eden, C. Lassen, J. Rade, M. Fontes, H. Morse, et al. Molecular signatures in childhood acute leukemia and their correlations to expression patterns in normal hematopoietic subpopulations PNAS, December 27, 2005; 102(52): 19069 - 19074. [Abstract] [Full Text] [PDF] L. Bullinger and P. J.M. Valk Gene Expression Profiling in Acute Myeloid Leukemia J. Clin. Oncol., September 10, 2005; 23(26): 6296 - 6305. [Abstract] [Full Text] [PDF] T. Matsunaga and M.-a. Muramatsu Knowledge-based computational search for genes associated with the metabolic syndrome Bioinformatics, July 15, 2005; 21(14): 3146 - 3154. [Abstract] [Full Text] [PDF] L. Li, J. Roden, B. E. Shapiro, B. J. Wold, S. Bhatia, S. J. Forman, and R. Bhatia Reproducibility, Fidelity, and Discriminant Validity of mRNA Amplification for Microarray Analysis from Primary Hematopoietic Cells J. Mol. Diagn., February 1, 2005; 7(1): 48 - 56. [Abstract] [Full Text] [PDF] M. E. Ross, R. Mahfouz, M. Onciu, H.-C. Liu, X. Zhou, G. Song, S. A. Shurtleff, S. Pounds, C. Cheng, J. Ma, et al. Gene expression profiling of pediatric acute myelogenous leukemia Blood, December 1, 2004; 104(12): 3679 - 3687. [Abstract] [Full Text] [PDF] D. Grimwade and T. Haferlach Gene-Expression Profiling in Acute Myeloid Leukemia N. Engl. J. Med., April 15, 2004; 350(16): 1676 - 1678. [Full Text] [PDF] B. Lowenberg, J. D. Griffin, and M. S. Tallman Acute Myeloid Leukemia and Acute Promyelocytic Leukemia Hematology, January 1, 2003; 2003(1): 82 - 101. [Abstract] [Full Text] [PDF]

	Copyright © 2003 by American Society of Hematology         Online ISSN: 1528-0020