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Prepublished online as a Blood First Edition Paper on July 10, 2003; DOI 10.1182/blood-2003-02-0583. This Article Full Text (PDF) All Versions of this Article: 2003-02-0583v1 102/13/4424    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pleass, R. J Articles by Woof, J. M Search for Related Content PubMed PubMed Citation Articles by Pleass, R. J Articles by Woof, J. M Social Bookmarking                   What's this? Submitted February 26, 2003 Accepted June 24, 2003 Novel anti-malarial antibodies highlight the importance of the antibody Fc region in mediating protection Richard J Pleass*, Solabomi A Ogun, David H McGuinness, Jan G van de Winkel, Anthony A Holder, and Jenny M Woof School of Life and Environmental Sciences, University of Nottingham, Nottingham, United Kingdom Division of Parasitology, National Institute for Medical Research, London, United Kingdom Department of Molecular and Cellular Pathology, University of Dundee, Dundee, United Kingdom Department of Immunology, University Medical Center Utrecht, Utrecht, The Netherlands * Corresponding author; email: richard.pleass{at}nottingham.ac.uk. Parasite drug resistance and difficulties in developing effective vaccines, have precipitated the search for alternative therapies for malaria. The success of passive immunization suggests that immunoglobulin-based therapies are effective. To further explore the mechanism(s) by which antibody mediates its protective effect, we generated human chimeric IgG1 and IgA1 and a single chain diabody specific for the C-terminal ~19 kDa region of Plasmodium yoelii merozoite surface protein 1 (MSP1-19), a major target of protective immune responses. These novel human reagents triggered in vitro phagocytosis of merozoites but unlike their parental mouse IgG2b, failed to protect against parasite challenge in vivo. Therefore, the Fc region appears critical for mediating protection in vivo, at least for this MSP1-19 epitope. Such antibodies may serve as prototype therapeutic agents, and as useful tools in the development of in vitro neutralization assays with Plasmodium parasites. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. E. H. Murhandarwati, L. Wang, H. D. de Silva, C. Ma, M. Plebanski, C. G. Black, and R. L. Coppel Growth-Inhibitory Antibodies Are Not Necessary for Protective Immunity to Malaria Infection Infect. Immun., February 1, 2010; 78(2): 680 - 687. [Abstract] [Full Text] [PDF] M. Lazarou, J. A. G. Patino, R. M. Jennings, R. S. McIntosh, J. Shi, S. Howell, E. Cullen, T. Jones, J. R. Adame-Gallegos, J. A. Chappel, et al. Inhibition of Erythrocyte Invasion and Plasmodium falciparum Merozoite Surface Protein 1 Processing by Human Immunoglobulin G1 (IgG1) and IgG3 Antibodies Infect. Immun., December 1, 2009; 77(12): 5659 - 5667. [Abstract] [Full Text] [PDF] E. E. H. Murhandarwati, L. Wang, C. G. Black, D. H. Nhan, T. L. Richie, and R. L. Coppel Inhibitory Antibodies Specific for the 19-Kilodalton Fragment of Merozoite Surface Protein 1 Do Not Correlate with Delayed Appearance of Infection with Plasmodium falciparum in Semi-Immune Individuals in Vietnam Infect. Immun., October 1, 2009; 77(10): 4510 - 4517. [Abstract] [Full Text] [PDF]

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