|
|
Prepublished online as a Blood First Edition Paper on May 29, 2003; DOI 10.1182/blood-2003-02-0637.
Submitted February 27, 2003
Accepted May 16, 2003
Anergic T cells exert antigen-independent inhibition of cell:cell interactions via chemokine metabolism
Martha J James, Lavina Belaramani, Kanella Prodromidou, Arpita Datta, Sussan Nourshargh, Giovanna Lombardi, Julian Dyson, Diane Scott, Elizabeth Simpson, Lorraine Cardozo, Anthony Warrens, Richard M Szydlo, Robert I Lechler, and Federica M Marelli-Berg*
Department of Immunology, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom
Cardiovascular Medicine Unit, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom
Transplantation Biology, Medical Research Council Clinical Research Centre, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom
Department of Hematology, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom
* Corresponding author; email: f.marelli{at}imperial.ac.uk.
Due to their ability to inhibit antigen-induced T cell activation in vitro and in vivo, anergic T cells can be considered part of the spectrum of immunoregulatory T lymphocytes. Here we report that both murine and human anergic T cells can impair the ability of parenchymal cells (including endothelial and epithelial cells) to establish cell: cell interactions necessary to sustain leukocyte migration in vitro and tissue infiltration in vivo. The inhibition is reversible, cell-contact dependent but does not require cognate recognition of the parenchymal cells to occur. Instrumental to this effect is the increased cell surface expression and enzymatic activity of molecules such as CD26 (dipeptidyl-peptidase IV), which may act by metabolising chemoattractants bound to the endothelial/epithelial cell surface. These results describe a previously unknown antigen-independent anti-inflammatory activity by locally generated anergic T cells, and define a novel mechanism for the long known immunoregulatory properties of these cells.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
R. David, L. Ma, A. Ivetic, A. Takesono, A. J. Ridley, J.-G. Chai, V. L. Tybulewicz, and F. M. Marelli-Berg
T-cell receptor- and CD28-induced Vav1 activity is required for the accumulation of primed T cells into antigenic tissue
Blood,
April 16, 2009;
113(16):
3696 - 3705.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
V. Mirenda, S. J. Jarmin, R. David, J. Dyson, D. Scott, Y. Gu, R. I. Lechler, K. Okkenhaug, and F. M. Marelli-Berg
Physiologic and aberrant regulation of memory T-cell trafficking by the costimulatory molecule CD28
Blood,
April 1, 2007;
109(7):
2968 - 2977.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z.-X. Zhang, Y. Ma, H. Wang, J. Arp, J. Jiang, X. Huang, K. M. He, B. Garcia, J. Madrenas, and R. Zhong
Double-Negative T Cells, Activated by Xenoantigen, Lyse Autologous B and T Cells Using a Perforin/Granzyme-Dependent, Fas-Fas Ligand-Independent Pathway
J. Immunol.,
November 15, 2006;
177(10):
6920 - 6929.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. K. Stevenson and F. Caligaris-Cappio
Chronic lymphocytic leukemia: revelations from the B-cell receptor
Blood,
June 15, 2004;
103(12):
4389 - 4395.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. M. Marelli-Berg, M. J. James, J. Dangerfield, J. Dyson, M. Millrain, D. Scott, E. Simpson, S. Nourshargh, and R. I. Lechler
Cognate recognition of the endothelium induces HY-specific CD8+ T-lymphocyte transendothelial migration (diapedesis) in vivo
Blood,
April 15, 2004;
103(8):
3111 - 3116.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
