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Prepublished online as a Blood First Edition Paper on June 5, 2003; DOI 10.1182/blood-2003-02-0649. This Article Full Text (PDF) All Versions of this Article: 2003-02-0649v1 102/7/2653    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Molloy, E. J Articles by Watson, R W. G Search for Related Content PubMed PubMed Citation Articles by Molloy, E. J Articles by Watson, R W. G Social Bookmarking                   What's this? Submitted February 28, 2003 Accepted May 23, 2003 Gender-specific alterations in neutrophil apoptosis: the role of estradiol and progesterone Eleanor J Molloy, Amanda J O'Neill, Julie J Grantham, Margaret Sheridan-Pereira, John M Fitzpatrick, David W Webb, and R William G Watson* Surgery, Mater Misericordiae University Hospital, Dublin, Ireland; Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland Surgery, Mater Misericordiae University Hospital, Dublin, Ireland Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland Paediatrics, Coombe Women's Hospital, Dublin, Ireland * Corresponding author; email: bwatson{at}mater.ie. Females are conferred with immunological and survival benefits, compared to males. Female sex steroids have been shown to contribute to this sexual dimorphism. Furthermore, during human pregnancy when female sex hormones are elevated neutrophil apoptosis is delayed. This study examines the specific effects of estradiol and progesterone on neutrophil apoptosis and function in normal adult males and females. We also examined the contribution of these hormones to the persistence and resolution of an inflammatory response. Spontaneous apoptosis was significantly decreased in females compared to males. Physiological doses of estradiol and progesterone caused a further delay in spontaneous apoptosis in both males and females but did not diminish Fas antibody induced apoptosis. The delay in apoptosis was mediated at the level of the mitochondria with decreased release of cytochrome c, which may alter caspase cleavage and activity. There were no associated alterations in neutrophil CD11b but reactive oxygen intermediates (ROI) production in females was increased. Thus, female sex hormones mediate delayed neutrophil apoptosis in both genders and enhance female intracellular ROI production. Modulating hormonal responses may be an effective therapeutic tool in combating inflammatory diseases. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R Nadif, V Siroux, M-P Oryszczyn, C Ravault, C Pison, I Pin, F Kauffmann, and on behalf of the Epidemiological study on the Gene Heterogeneity of asthma according to blood inflammatory patterns Thorax, May 1, 2009; 64(5): 374 - 380. [Abstract] [Full Text] [PDF] L. Faulkner, D. M. Altmann, S. Ellmerich, I. Huhtaniemi, G. Stamp, and S. Sriskandan Sexual Dimorphism in Superantigen Shock Involves Elevated TNF-{alpha} and TNF-{alpha} induced Hepatic Apoptosis Am. J. Respir. Crit. Care Med., September 1, 2007; 176(5): 473 - 482. [Abstract] [Full Text] [PDF] D. G. Healy, A. E. Wood, A. O'Neill, J. F. McCarthy, J. M. Fitzpatrick, and R. W. Watson Can preoperative modelling of individual neutrophil adhesion responses predict renal morbidity? Eur. J. Cardiothorac. Surg., June 1, 2007; 31(6): 1088 - 1093. [Abstract] [Full Text] [PDF] B. Lutton and I. Callard Evolution of reproductive-immune interactions Integr. Comp. Biol., December 1, 2006; 46(6): 1060 - 1071. [Abstract] [Full Text] [PDF] T. A. Williams, A. Verhovez, A. Milan, F. Veglio, and P. Mulatero Protective Effect of Spironolactone on Endothelial Cell Apoptosis Endocrinology, May 1, 2006; 147(5): 2496 - 2505. [Abstract] [Full Text] [PDF] X. Jiang, B. A. Orr, D. M. Kranz, and D. J. Shapiro Estrogen Induction of the Granzyme B Inhibitor, Proteinase Inhibitor 9, Protects Cells against Apoptosis Mediated by Cytotoxic T Lymphocytes and Natural Killer Cells Endocrinology, March 1, 2006; 147(3): 1419 - 1426. [Abstract] [Full Text] [PDF] A. Bouman, M. J. Heineman, and M. M. Faas Sex hormones and the immune response in humans Hum. Reprod. Update, July 1, 2005; 11(4): 411 - 423. [Abstract] [Full Text] [PDF] N. A. Maianski, D. Roos, and T. W. Kuijpers Bid Truncation, Bid/Bax Targeting to the Mitochondria, and Caspase Activation Associated with Neutrophil Apoptosis Are Inhibited by Granulocyte Colony-Stimulating Factor J. Immunol., June 1, 2004; 172(11): 7024 - 7030. [Abstract] [Full Text] [PDF]

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