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Prepublished online as a Blood First Edition Paper on June 26, 2003; DOI 10.1182/blood-2003-03-0692. This Article Full Text (PDF) All Versions of this Article: 2003-03-0692v1 102/8/2868    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Marafioti, T. Articles by Mason, D. Y Search for Related Content PubMed PubMed Citation Articles by Marafioti, T. Articles by Mason, D. Y Social Bookmarking                   What's this? Submitted March 4, 2003 Accepted June 5, 2003 Phenotype and genotype of interfollicular large B cells, a subpopulation of lymphocytes often with dendritic morphology Teresa Marafioti*, Margaret Jones, Fabio Facchetti, Tim C Diss, Ming-Qing Du, Peter G Isaacson, Michela Pozzobon, Stefano A Pileri, Amanda J Strickson, Soo-Yong Tan, Fiona Watkins, and David Y Mason Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, United Kingdom LRF Immunodiagnostics Unit, Nuffield Dept of Clinical Laboratory Sciences, University of Oxford, Oxford, United Kingdom Institute of Pathologic Anatomy, Brescia University, Brescia, Italy Department of Histopathology, University College Medical School, London, United Kingdom Pathologic Anatomy and Haematopathology Centre, Bologna University, Bologna, Italy LRF Molecular Haemtology Unit, Nuffield Dept of Clinical Laboratory Sciences, University of Oxford, Oxford, United Kingdom Department of Pathology and Laboratory Medicine, Tan Tock Seng Hospital, Tan Tock Seng, Singapore, Singapore * Corresponding author; email: teresa.marafioti{at}ndcls.ox.ac.uk. We describe large B cells, many of which have a stellate or dendritic morphology, found in the interfollicular T-cell-rich areas of human peripheral lymphoid tissue. These B cells probably require CD40/CD40 ligand signaling for their generation and have a unique phenotype and a "post-germinal center" pattern of immunoglobulin gene mutation. The only comparable B cell is the "asteroid" cell of the thymic medulla. Their anatomic location and pattern of gene mutation suggest that these cells may represent the cell of origin of some human large cell lymphomas. Studies in experimental animals should help to elucidate the role of these cells in the immune response. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. Le Pottier, V. Devauchelle, A. Fautrel, C. Daridon, A. Saraux, P. Youinou, and J.-O. 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