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Prepublished online as a Blood First Edition Paper on July 31, 2003; DOI 10.1182/blood-2003-03-0779. This Article Full Text (PDF) All Versions of this Article: 2003-03-0779v1 102/12/4143    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Boivin, D. B Articles by Sun, Z. S Search for Related Content PubMed PubMed Citation Articles by Boivin, D. B Articles by Sun, Z. S Social Bookmarking                   What's this? Submitted March 13, 2003 Accepted July 25, 2003 Circadian clock genes oscillate in human peripheral blood mononuclear cells Diane B Boivin, Francine O James, Aibin F Wu, Park F Cho-Park, Huabao Xiong, and Zhong S Sun* Center for Study and Treatment of Circadian Rhythms, Department of Psychiatry, Douglas Hospital and McGill University, Montreal, QC, Canada Division of Critical Care, Department of Pediatrics, Weill Medical College of Cornell University, New York, NY, USA Immunobiology Center, Mount Sinai School of Medicine, New York, NY, USA * Corresponding author; email: zss2001{at}med.cornell.edu. In mammals, it is well documented that observable circadian rhythms are controlled by a central oscillator that is organized in transcriptional and translational feedback loops involving several clock genes. Although recent studies have demonstrated that clock genes oscillate in many peripheral tissues, their characteristics in the human immune system remain unknown. The present study investigates whether circadian clock genes function in human peripheral blood mononuclear cells. Based on studies derived from three human subjects under controlled conditions, circadian clock genes hPer1, hPer2, hPer3 and hDec1 are expressed in a circadian manner in human peripheral blood mononuclear cells (PBMCs), with the peak level occurring during the habitual time of activity. The demonstration of functional circadian machinery in human PBMCs suggests that peripheral blood cells may be useful for the investigation of human circadian rhythms and their associated disorders. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. A. Martino and M. J. Sole Molecular Time: An Often Overlooked Dimension to Cardiovascular Disease Circ. Res., November 20, 2009; 105(11): 1047 - 1061. [Abstract] [Full Text] [PDF] E. J. Lewintre, C. R. Martin, C. G. Ballesteros, D. Montaner, R. F. Rivera, J. R. 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