|
|
Blood, 1 February 2004, Vol. 103, No. 3, pp. 973-979.
Prepublished online as a Blood First Edition Paper on October 2, 2003; DOI 10.1182/blood-2003-03-0874.
Submitted March 24, 2003
Accepted August 20, 2003
Elevated Interleukin-7 Levels are not Sufficient to Maintain T-cell Homeostasis During Simian Immunodeficiency Virus Induced Disease Progression
Alagarraju Muthukumar, Aneta Wozniakowski, Marie-Claire Gauduin, Mirko Paiardini, Harold M McClure, R Paul Johnson, Guido Silvestri, and Donald L Sodora*
Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, TX, USA
New England National Primate Research Center, Harvard Medical Center, Southborough, MA, USA
Yerkes Primate Research Center, Emory University, Atlanta, GA, USA; Institute of Biochemistry, University of Urbino, Italy
Yerkes Primate Research Center, Emory University, Atlanta, GA, USA
* Corresponding author; email: Donald.Sodora{at}UTSouthwestern.edu.
Elevated levels of interleukin (IL)-7 have been correlated with various T-cell depletion conditions including HIV infection and suggested as an indicator of HIV disease progression (AIDS and death). Here, the assessment of pathogenic simian immunodeficiency virus (SIVmac239) infection in rhesus macaques demonstrated a clear association between a significant elevation in IL-7 levels and disease progression. In five macaques that progressed to simian AIDS and death, elevated IL-7 levels were unable to restore T-cell homeostasis. In-contrast, increased IL-7 levels were followed by relatively high and stable T-cell numbers in the SIV-infected macaques with a slow progressing phenotype. Further, studies in sooty mangabeys that do not progress to simian AIDS and maintain stable T-cell numbers despite high levels of viral replication support the importance of IL-7 and T-cell homeostasis in disease progression. These data suggest that during pathogenic SIV infection with high viral replication, elevated IL-7 levels are unable to recover T-cell homeostasis thereby leading to disease progression. The utility of IL-7 as a potential immunotherapeutic to improve HIV/SIV related T-cell depletion may therefore depend on controlling the pathogenic effects of viral replication prior to the IL-7 administration.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
A. Durudas, J. M. Milush, H.-L. Chen, J. C. Engram, G. Silvestri, and D. L. Sodora
Elevated Levels of Innate Immune Modulators in Lymph Nodes and Blood Are Associated with More-Rapid Disease Progression in Simian Immunodeficiency Virus-Infected Monkeys
J. Virol.,
December 1, 2009;
83(23):
12229 - 12240.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Estes, S. N. Gordon, M. Zeng, A. M. Chahroudi, R. M. Dunham, S. I. Staprans, C. S. Reilly, G. Silvestri, and A. T. Haase
Early Resolution of Acute Immune Activation and Induction of PD-1 in SIV-Infected Sooty Mangabeys Distinguishes Nonpathogenic from Pathogenic Infection in Rhesus Macaques
J. Immunol.,
May 15, 2008;
180(10):
6798 - 6807.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. N. Gordon, R. M. Dunham, J. C. Engram, J. Estes, Z. Wang, N. R. Klatt, M. Paiardini, I. V. Pandrea, C. Apetrei, D. L. Sodora, et al.
Short-Lived Infected Cells Support Virus Replication in Sooty Mangabeys Naturally Infected with Simian Immunodeficiency Virus: Implications for AIDS Pathogenesis
J. Virol.,
April 1, 2008;
82(7):
3725 - 3735.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Hryniewicz, D. A. Price, M. Moniuszko, A. Boasso, Y. Edghill-Spano, S. M. West, D. Venzon, M. Vaccari, W.-P. Tsai, E. Tryniszewska, et al.
Interleukin-15 but Not Interleukin-7 Abrogates Vaccine-Induced Decrease in Virus Level in Simian Immunodeficiency Virusmac251-Infected Macaques
J. Immunol.,
March 15, 2007;
178(6):
3492 - 3504.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. S. Albuquerque, C. S. Cortesao, R. B. Foxall, R. S. Soares, R. M. M. Victorino, and A. E. Sousa
Rate of Increase in Circulating IL-7 and Loss of IL-7R{alpha} Expression Differ in HIV-1 and HIV-2 Infections: Two Lymphopenic Diseases with Similar Hyperimmune Activation but Distinct Outcomes
J. Immunol.,
March 1, 2007;
178(5):
3252 - 3259.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. VandeWoude and C. Apetrei
Going Wild: Lessons from Naturally Occurring T-Lymphotropic Lentiviruses
Clin. Microbiol. Rev.,
October 1, 2006;
19(4):
728 - 762.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Swainson, E. Verhoeyen, F.-L. Cosset, and N. Taylor
IL-7R{alpha} Gene Expression Is Inversely Correlated with Cell Cycle Progression in IL-7-Stimulated T Lymphocytes.
J. Immunol.,
June 1, 2006;
176(11):
6702 - 6708.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Muthukumar, D. Zhou, M. Paiardini, A. P. Barry, K. S. Cole, H. M. McClure, S. I. Staprans, G. Silvestri, and D. L. Sodora
Timely triggering of homeostatic mechanisms involved in the regulation of T-cell levels in SIVsm-infected sooty mangabeys
Blood,
December 1, 2005;
106(12):
3839 - 3845.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-D. Lelievre, F. Petit, D. Arnoult, J.-C. Ameisen, and J. Estaquier
Interleukin 7 Increases Human Immunodeficiency Virus Type 1 LAI-Mediated Fas-Induced T-Cell Death
J. Virol.,
March 1, 2005;
79(5):
3195 - 3199.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Picker, S. I. Hagen, R. Lum, E. F. Reed-Inderbitzin, L. M. Daly, A. W. Sylwester, J. M. Walker, D. C. Siess, M. Piatak Jr., C. Wang, et al.
Insufficient Production and Tissue Delivery of CD4+ Memory T Cells in Rapidly Progressive Simian Immunodeficiency Virus Infection
J. Exp. Med.,
November 15, 2004;
200(10):
1299 - 1314.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
