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Blood, 15 February 2004, Vol. 103, No. 4, pp. 1542-1547. Prepublished online as a Blood First Edition Paper on October 16, 2003; DOI 10.1182/blood-2003-03-0957. This Article Full Text (PDF) All Versions of this Article: 2003-03-0957v1 103/4/1542    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Petrovic, A. Articles by van den Brink, M. R M Search for Related Content PubMed PubMed Citation Articles by Petrovic, A. Articles by van den Brink, M. R M Social Bookmarking                   What's this? Submitted March 31, 2003 Accepted October 6, 2003 LPAM (47 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal Graft-Versus-Host Disease Aleksandra Petrovic, Onder Alpdogan, Lucy M Willis, Jeffrey M Eng, Andrew S Greenberg, Barry J Kappel, Chen Liu, George Murphy, Glenn Heller, and Marcel R M van den Brink* Department of Pediatrics and Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY, USA Department of Pathology, University of Florida, Gainesville, FL, USA Department of Pathology, Thomas Jefferson Medical Center, Philadelphia, PA, USA * Corresponding author; email: vandenbm{at}mskcc.org. Lymphocyte Peyer's patch adhesion molecule (LPAM) or 47 integrin is expressed on lymphocytes and is responsible for T cell homing into gut associated lymphoid tissues through its binding to mucosal addressing cell adhesion molecule (MAdCAM), which is present on high endothelial venules of mucosal lymphoid organs. We found in murine allogeneic bone marrow transplantation (BMT) models that recipients of 47- donor T cells had significantly less GVHD morbidity and mortality compared to recipients of 47+ donor T cells. A kinetic posttransplant analysis of lymphocytes in the intestines and mesenteric lymph nodes demonstrated a delayed invasion of lower numbers of 47+ T cells in recipients of 47- T cells compared to recipients of 47+ T cells. Histopathologic analysis of GVHD target organs revealed that recipients of 47- T cells developed less GVHD of the intestines and liver, whereas there was no difference in cutaneous and thymic GVHD between recipients of 47- or 47+ T cells. Finally, we found that in vivo GVT activity of 47- donor T cells was preserved. We conclude that the 47 integrin is important for the invasion of alloreactive donor T cells into the gut and the subsequent development of intestinal GVHD and overall GVHD morbidity and mortality. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. Socie and B. R. Blazar Acute graft-versus-host disease: from the bench to the bedside Blood, November 12, 2009; 114(20): 4327 - 4336. [Abstract] [Full Text] [PDF] L. W. Kappel, G. L. Goldberg, C. G. King, D. Y. Suh, O. M. Smith, C. Ligh, A. M. Holland, J. Grubin, N. M. Mark, C. Liu, et al. IL-17 contributes to CD4-mediated graft-versus-host disease Blood, January 22, 2009; 113(4): 945 - 952. [Abstract] [Full Text] [PDF] N. Beyersdorf, X. Ding, G. Blank, K. M. Dennehy, T. Kerkau, and T. 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