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Prepublished online as a Blood First Edition Paper on June 26, 2003; DOI 10.1182/blood-2003-03-0967. This Article Full Text (PDF) All Versions of this Article: 2003-03-0967v1 102/8/2910    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Franchi, L. Articles by Testi, R. Search for Related Content PubMed PubMed Citation Articles by Franchi, L. Articles by Testi, R. Social Bookmarking                   What's this? Submitted March 28, 2003 Accepted June 16, 2003 A caspase-like activity is triggered by LPS and is required for survival of human dendritic cells Luigi Franchi, Ivano Condo', Barbara Tomassini, Chiara Nicolo', and Roberto Testi* Department of Experimental Medicine and Biochemical Sciences, University of Rome 'Tor Vergata', Rome, Italy * Corresponding author; email: tesrob{at}flashnet.it. Bacterial endotoxin (lipopolysaccharide, LPS) is a potent inducer of human dendritic cell (DC) maturation and survival. Here we show that immature DC exposed to LPS trigger an early and sustained caspase-like activity, which can be blocked by zVAD, in the absence of detectable caspase 8 and caspase 10 activation, or PARP-cleaving activity. Preventing LPS-induced caspase-like activation in DC results in massive cell death. Importantly, triggering of the caspase-like activity is required for LPS-induced activation of ERKs and for LPS-induced upregulation of cFLIP. Therefore, a caspase-dependent pathway initiated by LPS controls survival of human DC. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Illario, M. L. Giardino-Torchia, U. Sankar, T. J. Ribar, M. Galgani, L. Vitiello, A. M. Masci, F. R. Bertani, E. Ciaglia, D. Astone, et al. Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells Blood, January 15, 2008; 111(2): 723 - 731. [Abstract] [Full Text] [PDF] A. Nencioni, K. Schwarzenberg, K. M. Brauer, S. M. Schmidt, A. Ballestrero, F. Grunebach, and P. Brossart Proteasome inhibitor bortezomib modulates TLR4-induced dendritic cell activation Blood, July 15, 2006; 108(2): 551 - 558. [Abstract] [Full Text] [PDF] Y. Xu, S. O. Kim, Y. Li, and J. Han Autophagy Contributes to Caspase-independent Macrophage Cell Death J. Biol. Chem., July 14, 2006; 281(28): 19179 - 19187. [Abstract] [Full Text] [PDF] L. Frasca, G. Fedele, S. Deaglio, C. Capuano, R. Palazzo, T. Vaisitti, F. Malavasi, and C. M. Ausiello CD38 orchestrates migration, survival, and Th1 immune response of human mature dendritic cells Blood, March 15, 2006; 107(6): 2392 - 2399. [Abstract] [Full Text] [PDF] L. Franchi, F. Malisan, B. Tomassini, and R. Testi Ceramide catabolism critically controls survival of human dendritic cells J. Leukoc. Biol., January 1, 2006; 79(1): 166 - 172. [Abstract] [Full Text] [PDF] H. S. Kim and M.-S. Lee Essential Role of STAT1 in Caspase-Independent Cell Death of Activated Macrophages through the p38 Mitogen-Activated Protein Kinase/STAT1/Reactive Oxygen Species Pathway Mol. Cell. Biol., August 1, 2005; 25(15): 6821 - 6833. [Abstract] [Full Text] [PDF] T.-B. Kang, T. Ben-Moshe, E. E. Varfolomeev, Y. Pewzner-Jung, N. Yogev, A. Jurewicz, A. Waisman, O. Brenner, R. Haffner, E. Gustafsson, et al. Caspase-8 Serves Both Apoptotic and Nonapoptotic Roles J. Immunol., September 1, 2004; 173(5): 2976 - 2984. [Abstract] [Full Text] [PDF] X. Chen, K. Doffek, S. L. Sugg, and J. Shilyansky Phosphatidylserine Regulates the Maturation of Human Dendritic Cells J. Immunol., September 1, 2004; 173(5): 2985 - 2994. [Abstract] [Full Text] [PDF]

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