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Prepublished online as a Blood First Edition Paper on July 24, 2003; DOI 10.1182/blood-2003-04-1016. This Article Full Text (PDF) Supplemental Data All Versions of this Article: 2003-04-1016v1 102/10/3693    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Brandes, M. Articles by Moser, B. Search for Related Content PubMed PubMed Citation Articles by Brandes, M. Articles by Moser, B. Social Bookmarking                   What's this? Submitted April 3, 2003 Accepted July 9, 2003 Flexible migration program regulates T-cell involvement in humoral immunity Marlene Brandes, Katharina Willimann, Alois B Lang, Ki-Hoan Nam, Chenggang Jin, Michael B Brenner, Craig T Morita, and Bernhard Moser* Theodor-Kocher Institute, University of Bern, Bern, Switzerland Research Division, Berna Biotech Ltd., Bern, Switzerland Division of Rheumatology, Department of Internal Medicine and the Interdisciplinary Group in Immunology, University of Iowa College of Medicine, Iowa City, IA, USA Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA * Corresponding author; email: bernhard.moser{at}tki.unibe.ch. T cells are inadequately defined both in terms of their migration potential and contribution to anti-microbial immunity. Here, we have examined the migration profile of human blood T cells and related cell lines and correlated these findings with their distribution in secondary lymphoid tissues, and their function in B cell co-cultures. We find that resting T cells are characterized by an inflammatory migration program similar to cells of the innate immune system. However, T cell receptor triggering resulted in the rapid but transient induction of a LN-homing program, as evidenced by functional CCR7 expression and concomitant reduction in expression and function of CCR5 and, to a lesser degree, CCR2. Moreover, the LN homing program was reflected by the presence of T cells in gastrointestinal lymphoid tissues, notably in clusters within germinal centres of B cell follicles. In line with these findings, VV-TCR triggering resulted in prominent expression of essential B cell co-stimulatory molecules, including CD40L, OX40, CD70 and ICOS. 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