|
|
Prepublished online as a Blood First Edition Paper on June 26, 2003; DOI 10.1182/blood-2003-04-1128.
Submitted April 10, 2003
Accepted June 12, 2003
Outcome heterogeneity in childhood high hyperdiploid acute lymphoblastic leukemia
Anthony V Moorman*, Sue M Richards, Mary Martineau, Kan Luk Cheung, Hazel M Robinson, Gholam R Jalali, Zoe J Broadfield, Rachel L Harris, Kerry E Taylor, Brenda E Gibson, Ian M Hann, Frank G Hill, Sally E Kinsey, Tim O Eden, Christopher D Mitchell, and Christine J Harrison
LRF Cytogenetics Group, Cancer Sciences Division, University of Southampton, Southampton, United Kingdom
Clinical Trial Service Unit, University of Oxford, Oxford, United Kingdom
Department of Haematology, Yorkhill NHS Trust, Glasgow, United Kingdom
Department of Haematology, Great Ormond Street Hospital, London, United Kingdom
Department of Haematology, Birmingham Children's Hospital NHS Trust, Birmingham, United Kingdom
St. James Hospital, Leeds, United Kingdom
Department of Haematology, Central Manchester and Manchester Children's University Hospitals Trust, Manchester, United Kingdom
Department of Haematology, John Radcliffe Hospital, Oxford, United Kingdom
* Corresponding author; email: avm{at}soton.ac.uk.
High hyperdiploidy (HeH) (51-65 chromosomes) is found in one third of children with acute lymphoblastic leukemia and is associated with a good prognosis. Cytogenetic features may further refine this prognosis and identify patients with a poor outcome. We examined the effect of sex, age, individual trisomies, modal number and structural abnormalities on survival, among 700 children with HeH. Univariate analysis showed that age, sex, +4, +10, +18 and a high modal number were associated with survival. Multivariate analysis however, revealed that only age, sex, +4 and +18 were independent indicators. Hazard scores for predicting relapse and mortality were constructed. Three risk groups with 5-year event-free survival (EFS) rates of 86%, 75% and 50% (p<0.0001) were identified. The high risk group comprised: boys aged >9 years, boys aged 1-9 years without +18 and girls >9 years without +18, while girls aged 1-9 years with +18 had the best EFS. In terms of mortality, those aged <10 years with both +4 and +18 had an improved survival (96% versus 84% at 5 years, p<0.0001). These findings confirm that the outcome of children with HeH is heterogeneous and that specific trisomies can identify patients with the greatest and least risk of treatment failure.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
D. French, W. Yang, C. Cheng, S. C. Raimondi, C. G. Mullighan, J. R. Downing, W. E. Evans, C.-H. Pui, and M. V. Relling
Acquired variation outweighs inherited variation in whole genome analysis of methotrexate polyglutamate accumulation in leukemia
Blood,
May 7, 2009;
113(19):
4512 - 4520.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Sulong, A. V. Moorman, J. A. E. Irving, J. C. Strefford, Z. J. Konn, M. C. Case, L. Minto, K. E. Barber, H. Parker, S. L. Wright, et al.
A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups
Blood,
January 1, 2009;
113(1):
100 - 107.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Davidsson, A. Andersson, K. Paulsson, M. Heidenblad, M. Isaksson, A. Borg, J. Heldrup, M. Behrendtz, I. Panagopoulos, T. Fioretos, et al.
Tiling resolution array comparative genomic hybridization, expression and methylation analyses of dup(1q) in Burkitt lymphomas and pediatric high hyperdiploid acute lymphoblastic leukemias reveal clustered near-centromeric breakpoints and overexpression of genes in 1q22-32.3
Hum. Mol. Genet.,
September 15, 2007;
16(18):
2215 - 2225.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. R. Chauvenet, P. L. Martin, M. Devidas, S. B. Linda, B. A. Bell, J. Kurtzberg, J. Pullen, M. J. Pettenati, A. J. Carroll, J. J. Shuster, et al.
Antimetabolite therapy for lesser-risk B-lineage acute lymphoblastic leukemia of childhood: a report from Children's Oncology Group Study P9201
Blood,
August 15, 2007;
110(4):
1105 - 1111.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. B. Nachman, N. A. Heerema, H. Sather, B. Camitta, E. Forestier, C. J. Harrison, N. Dastugue, M. Schrappe, C.-H. Pui, G. Basso, et al.
Outcome of treatment in children with hypodiploid acute lymphoblastic leukemia
Blood,
August 15, 2007;
110(4):
1112 - 1115.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. V. Moorman, C. J. Harrison, G. A. N. Buck, S. M. Richards, L. M. Secker-Walker, M. Martineau, G. H. Vance, A. M. Cherry, R. R. Higgins, A. K. Fielding, et al.
Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial
Blood,
April 15, 2007;
109(8):
3189 - 3197.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. C. Aldrich, L. Zhang, J. L. Wiemels, X. Ma, M. L. Loh, C. Metayer, S. Selvin, J. Feusner, M. T. Smith, and P. A. Buffler
Cytogenetics of Hispanic and white children with acute lymphoblastic leukemia in california.
Cancer Epidemiol. Biomarkers Prev.,
March 1, 2006;
15(3):
578 - 581.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Brown, M. Levis, S. Shurtleff, D. Campana, J. Downing, and D. Small
FLT3 inhibition selectively kills childhood acute lymphoblastic leukemia cells with high levels of FLT3 expression
Blood,
January 15, 2005;
105(2):
812 - 820.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
