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Prepublished online as a Blood First Edition Paper on September 25, 2003; DOI 10.1182/blood-2003-04-1155. This Article Full Text (PDF) All Versions of this Article: 2003-04-1155v1 103/2/383    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Nieda, M. Articles by Nicol, A. J Search for Related Content PubMed PubMed Citation Articles by Nieda, M. Articles by Nicol, A. J Social Bookmarking                   What's this? Submitted April 23, 2003 Accepted September 9, 2003 Therapeutic activation of V24+V11+NKT cells in human subjects results in highly co-ordinated secondary activation of acquired and innate immunity Mie Nieda, Miki Okai, Andrea Tazbirkova, Henry Lin, Ayako Yamaura, Kazuki Ide, Takeo Juji, David J Macfarlane, and Andrew J Nicol* Queensland Institute of Medical Research, Brisbane, QLD, Australia Department of Medicine, University of Queensland, Brisbane, QLD, Australia Departments of Oncology and Nuclear Medicine, Royal Brisbane Hospital, Brisbane, QLD, Australia Yokohama City University School of Medicine, Yokohama, Japan Japanese Red Cross, Tokyo, Japan Queensland Institute of Medical Research, Brisbane, QLD, Australia; Department of Medicine, University of Queensland, Brisbane, QLD, Australia; Departments of Oncology and Nuclear Medicine, Royal Brisbane Hospital, Brisbane, QLD, Australia * Corresponding author; email: andrewN{at}qimr.edu.au. Human V24+V11+NKT cells are a distinct CD1d restricted lymphoid subset specifically and potently activated by -GalactosylCeramide (-GalCer; KRN7000) presented by CD1d on antigen presenting cells. Preclinical models show that activation of V24+V11+NKT cells induces effective antitumor immune responses and potentially important secondary immune effects, including activation of conventional T cells and NK cells. We describe the first clinical trial of cancer immune therapy with -GalCer pulsed CD1d expressing dendritic cells. The results show that this therapy has substantial, rapid and highly reproducible specific effects on V24+V11+NKT cells and provide the first human in vivo evidence that V24+V11+NKT cell stimulation leads to activation of both innate and acquired immunity, resulting in modulation of NK, T and B cell numbers and increased serum interferon-. We present the first clinical evidence that V24+V11+NKT cell memory produces faster, more vigorous secondary immune responses by innate and acquired immunity upon restimulation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Taniguchi, T. Tashiro, N. Dashtsoodol, N. Hongo, and H. Watarai The specialized iNKT cell system recognizes glycolipid antigens and bridges the innate and acquired immune systems with potential applications for cancer therapy Int. Immunol., October 27, 2009; (2009) dxp104v2. [Abstract] [Full Text] [PDF] D. Bagnara, A. Ibatici, M. Corselli, N. Sessarego, C. Tenca, A. De Santanna, A. Mazzarello, A. Daga, R. Corvo, G. De Rossi, et al. Adoptive immunotherapy mediated by ex vivo expanded natural killer T cells against CD1d-expressing lymphoid neoplasms Haematologica, July 1, 2009; 94(7): 967 - 974. [Abstract] [Full Text] [PDF] C. H. Tripp, F. Sparber, I. F. Hermans, N. 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