SEARCH:   Advanced

Blood, 1 February 2004, Vol. 103, No. 3, pp. 1171-1174. Prepublished online as a Blood First Edition Paper on October 2, 2003; DOI 10.1182/blood-2003-04-1187. This Article Full Text (PDF) All Versions of this Article: 2003-04-1187v1 103/3/1171    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gilroy, R. K Articles by Horslen, S. P Search for Related Content PubMed PubMed Citation Articles by Gilroy, R. K Articles by Horslen, S. P Social Bookmarking                   What's this? Submitted April 16, 2003 Accepted September 28, 2003 Donor immune reconstitution after liver-small bowel transplantation for multiple intestinal atresia with immunodeficiency Richard K Gilroy, Peter F Coccia*, James E Talmadge, Lori I Hatcher, Samuel J Pirruccello, Byers W Shaw, Ronald J Rubocki, Debra L Sudan, Alan N Langnas, and Simon P Horslen Departments of Internal Medicine, Pediatric Hematology/Oncology, Pathology and Microbiology, Surgery, and Pediatrics Gastroenterology, University of Nebraska Medical Center, Omaha, NE, USA * Corresponding author; email: pcoccia{at}unmc.edu. The syndrome of multiple intestinal atresia with immunodeficiency is a rare invariably fatal congenital disorder. At 16 months of age, a child with this syndrome underwent liver-small bowel transplantation from a 1 of 6 HLA-matched donor. He developed full enteral tolerance and normal liver function; and has never had evidence of allograft rejection. After development of mild graft-versus-host disease, studies revealed that over 99% of his CD3+ lymphocytes and 50% of his CD19+ lymphocytes were of donor origin while granulocytes and monocytes remained of recipient origin. He synthesizes polyclonal IgG, IgA, and IgM and has developed antibodies to CMV and parainfluenza III. His T lymphocytes are predominately CD3+CD4-CD8- with T cell receptor heterodimers and CD3+CD4-CD8+ with CD8 homodimers, populations consistent with an intraepithelial lymphocyte phenotypic profile. We postulate he has engrafted a donor intestine derived immune system and is incapable of rejecting his engrafted organs. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. I. Alexander, N. Smith, M. Hu, D. Verran, A. Shun, S. Dorney, A. Smith, B. Webster, P. J. Shaw, A. Lammi, et al. Chimerism and Tolerance in a Recipient of a Deceased-Donor Liver Transplant N. Engl. J. Med., January 24, 2008; 358(4): 369 - 374. [Abstract] [Full Text] [PDF] H. Yarmohammadi, L. Estrella, J. Doucette, and C. Cunningham-Rundles Recognizing primary immune deficiency in clinical practice. Clin. Vaccine Immunol., March 1, 2006; 13(3): 329 - 332. [Abstract] [Full Text] [PDF]

	Copyright © 2003 by American Society of Hematology         Online ISSN: 1528-0020