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Blood, 15 October 2004, Vol. 104, No. 8, pp. 2444-2451. Prepublished online as a Blood First Edition Paper on March 23, 2004; DOI 10.1182/blood-2003-04-1299. This Article Full Text (PDF) All Versions of this Article: 2003-04-1299v1 104/8/2444    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by CHARRIN, C. Articles by DASTUGUE, N. Search for Related Content PubMed PubMed Citation Articles by CHARRIN, C. Articles by DASTUGUE, N. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 25, 2003 Accepted February 29, 2004 Hypodiploidy with 30-39 chromosomes and near-triploidy: two possible expressions of a sole entity conferring poor prognosis in Adult Acute Lymphoblastic Leukemia (ALL). A report from the LALA-94 and LALA-SA Groups CHRISTIANE CHARRIN*, XAVIER THOMAS, MARTINE FFRENCH, QUOC-HUNG LE, JORIS ANDRIEUX, MARIE JOELLE MOZZICONACCI, JEAN-LUC LAI, CHRYSTELE BILHOU-NABERA, LUCIENNE MICHAUX, ALAIN BERNHEIM, CHRISTIAN BASTARD, HOSSEIN MOSSAFA, CHRISTINE PEROT, ODILE MAAREK, CLAUDE BOUCHEIX, VERONIQUE LHERITIER, ANDRE DELANNOY, DENIS FIERE, and NICOLE DASTUGUE HEMATOLOGY, HOPITAL EDOUARD HERRIOT, LYON, France HEMATOLOGY, HOPITAL EDOUARD HERRIOT, LYON, France; BIOSTATISTIC, CENTRE HOSPITALIER LYON SUD, PIERRE BENITE, France HEMATOLOGY, HOPITAL CLAUDE HURIEZ, LILLE, France HEMATOLOGY, INSTITUT PAOLI CALMETTES, MARSEILLE, France HEMATOLOGY, HOPITAL DU HAUT LEVEQUE, BORDEAUX, France HEMATOLOGY, CLINIQUES ST LUC, BRUSSELS, Belgium HEMATOLOGY, INSTITUT GUSTAVE ROUSSY, VILLEJUIF, France HEMATOLOGY, CENTRE HENRI BECQUEREL, ROUEN, France HEMATOLOGY, LABORATOIRE CERBA, VAL D'OISE, France HEMATOLOGY, HOPITAL SAINT ANTOINE, PARIS, France HEMATOLOGY, HOPITAL SAINT LOUIS, PARIS, France U268, INSERM, VILLEJUIF, France HEMATOLOGY, HOPITAL JOLIMONT, HAINE SAINT PAUL, Belgium HEMATOLOGY, HOPITAL PURPAN, TOULOUSE, France * Corresponding author; email: christiane.charrin{at}chu-lyon.fr. To reveal the relationship between hypodiploidy with 30-39 chromosomes and near-triploidy in acute lymphoblastic leukemia (ALL), we studied 24 patients presenting with one of these aneuploidies among 623 adult ALLs registered in the LALA protocols. The two ploidy groups presented a striking similarity of their cytogenetic profiles: chromosomes 2, 3, 4, 7, 13, 15, 16 and 17 significantly monosomic in hypodiploidy 30-39, were also frequently disomic in near-triploidy , whereas those retained in pairs in hypodiploidy 30-39 were frequently tetrasomic in near-triploidy. DNA content data revealed the simultaneous presence of two aneuploid peaks in most tested cases (DNA indexes: 0.72-0.87/1.39-1.89) and a multiple correspondence analysis applied on cytogenetic profiles ascertained their strong relationship. We thus assumed that near-triploidy derives from the duplication of hypodiploidy 30-39 chromosomes, and that both aneuploid groups are two expressions of the same disease. These 24 patients presented with B-cell phenotype, low leukocytoses (median WBC: 4.2x109/L) and poor prognosis (complete remission [CR] 57%, median disease-free-survival [DFS] 8 months, median survival 10.4 months) comparable to that of Ph-positive patients treated according to the same protocol. We suggest that hypodiploidy with 30-39 chromosomes or near-triploidy, should be regarded as a new high risk factor in the risk stratification of adult ALL protocols. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Bassan, O. Spinelli, E. Oldani, T. Intermesoli, M. Tosi, B. Peruta, G. Rossi, E. Borlenghi, E. M. Pogliani, E. Terruzzi, et al. Improved risk classification for risk-specific therapy based on the molecular study of minimal residual disease (MRD) in adult acute lymphoblastic leukemia (ALL) Blood, April 30, 2009; 113(18): 4153 - 4162. [Abstract] [Full Text] [PDF] F. Huguet, T. Leguay, E. 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V. Moorman, C. J. Harrison, G. A. N. Buck, S. M. Richards, L. M. Secker-Walker, M. Martineau, G. H. Vance, A. M. Cherry, R. R. Higgins, A. K. Fielding, et al. Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII/Eastern Cooperative Oncology Group (ECOG) 2993 trial Blood, April 15, 2007; 109(8): 3189 - 3197. [Abstract] [Full Text] [PDF]

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