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Prepublished online as a Blood First Edition Paper on July 31, 2003; DOI 10.1182/blood-2003-04-1323. This Article Full Text (PDF) All Versions of this Article: 2003-04-1323v1 102/10/3652    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by He, L. Articles by Zutter, M. M Search for Related Content PubMed PubMed Citation Articles by He, L. Articles by Zutter, M. M Social Bookmarking                   What's this? Submitted April 28, 2003 Accepted July 23, 2003 The contributions of the 21 integrin to vascular thrombosis in vivo Li He, Loretta K Pappan, David G Grenache, Zhengzhi Li, Douglas M Tollefsen, Samuel A Santoro, and Mary M Zutter* Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO, USA; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA * Corresponding author; email: mary.zutter{at}vanderbilt.edu. The 21 integrin serves as a receptor for collagens, laminin, and/or several other nonmatrix ligands. Many studies have suggested that the 21 integrin is a critical mediator of platelet adhesion to collagen within the vessel wall after vascular injury and that the interactions of the platelet 21 integrin with subendothelial collagen after vascular injury are required for proper hemostasis. We have used the 21 integrin-deficient mouse to evaluate the contributions of the 21 integrin in two in vivo models of thrombosis. Studies using a model of endothelial injury to the carotid artery reveal that the 21 integrin plays a critical role in vascular thrombosis at the blood-vessel wall interface under flow conditions. In contrast, the 21 integrin is not required for the formation of thrombi and pulmonary emboli following intravascular injection of collagen. Our results are the first to document a critical in vivo role for the 21 integrin in thrombus formation at the vessel wall under conditions of shear following vascular injury. 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