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Blood, 1 February 2004, Vol. 103, No. 3, pp. 1026-1029. Prepublished online as a Blood First Edition Paper on October 2, 2003; DOI 10.1182/blood-2003-04-1339. This Article Full Text (PDF) Supplemental Tables All Versions of this Article: 2003-04-1339v1 103/3/1026    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Longman, R. S Articles by Rice, C. M Search for Related Content PubMed PubMed Citation Articles by Longman, R. S Articles by Rice, C. M Social Bookmarking                   What's this? Submitted May 1, 2003 Accepted August 27, 2003 Patients chronically infected with hepatitis C virus have functional dendritic cells Randy S Longman, Andrew H Talal, Ira M Jacobson, Matthew L Albert*, and Charles M Rice Laboratory of Neuro-oncology, The Rockefeller University, New York, NY, USA; Department of Pathology, The New York Presbyterian Hospital, New York, NY, USA The Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA Department of Medicine, The New York Presbyterian Hospital, New York, NY, USA * Corresponding author; email: albertm{at}pasteur.fr. The absence of expanded numbers of HCV-reactive CD8+ T lymphocytes (CTLs) in patients chronically infected with hepatitis C virus (HCV) has led to the investigation of dendritic cell (DC) function in this population as a potential cause for this defect. Several studies have shown evidence for impaired monocyte-derived DCs in chronically infected patients. As it is difficult to reconcile this data with the fact that chronic HCV patients are immune-competent, we re-evaluated this finding, carefully assessing phenotypic markers and functional activity of patient DCs as compared to normal controls. In contrast to these prior studies, DCs from 13/13 chronic HCV patients expressed typical maturation markers. These mature DCs are capable of priming allogeneic T lymphocytes, as well as stimulating influenza-specific memory T cells. This finding is consistent with clinical and immunologic data that the deficit in the patient's immune repertoire is HCV-specific and requires refined models for the role of DCs in HCV pathogenesis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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