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Prepublished online as a Blood First Edition Paper on July 17, 2003; DOI 10.1182/blood-2003-05-1374. This Article Full Text (PDF) All Versions of this Article: 2003-05-1374v1 102/9/3287    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Maecker, B. Articles by Schultze, J. L Search for Related Content PubMed PubMed Citation Articles by Maecker, B. Articles by Schultze, J. L Social Bookmarking                   What's this? Submitted May 12, 2003 Accepted June 30, 2003 The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells Britta Maecker, David H Sherr, Robert H Vonderheide, Michael S von Bergwelt-Baildon, Naoto Hirano, Karen S Anderson, Zhinan Xia, Marcus O Butler, Kai W Wucherpfennig, Carl O'Hara, Geoffrey Cole, Silvia S Kwak, Urban Ramstedt, Andy J Tomlinson, Roman M Chicz, Lee M Nadler, and Joachim L Schultze* Department for Adult Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department for Medicine, Brigham and Women's Hospital, Boston, MA, USA; Molecular Tumor Biology and Tumor Immunology, University of Cologne, Cologne, Germany Department of Environmental Health, Boston University School of Public Health, Boston, MA, USA Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA, USA Department of Pathology and Laboratory Medicine, Boston University, Boston, MA, USA Zycos, Inc., Lexington, MA, USA * Corresponding author; email: joachim.schultze{at}medizin.uni-koeln.de. Cytochrome P450 1B1 (CYP1B1), a drug metabolizing extrahepatic enzyme, was recently shown to be overexpressed in multiple types of cancer. Such tumor-associated genes may be useful targets for anti-cancer therapy, particularly cancer immunotherapeutics. We identified HLA-A*0201 binding peptides and a naturally processed and presented T cell epitope capable of inducing CYP1B1 specific CTL in HLA-A2 transgenic mice. Furthermore, induction of CYP1B1 specific T cells was demonstrated in healthy donors and cancer patients. These T cells efficiently lysed target cells pulsed with the cognate peptide. More important, HLA-A2 matched tumor cell lines and primary malignant cells were also recognized by CYP1B1 specific CTL. These findings form the basis of a phase I clinical trial exploring a DNA-based vector encoding CYP1B1 for widely applicable cancer immunotherapy conducted at Dana-Farber Cancer Institute. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. A. Vella, M. Yu, S. R. Fuhrmann, M. El-Amine, D. E. Epperson, and O. J. Finn Healthy individuals have T-cell and antibody responses to the tumor antigen cyclin B1 that when elicited in mice protect from cancer PNAS, August 18, 2009; 106(33): 14010 - 14015. [Abstract] [Full Text] [PDF] W. R. Ware Nutrition and the Prevention and Treatment of Cancer: Association of Cytochrome P450 CYP1B1 With the Role of Fruit and Fruit Extracts Integr Cancer Ther, March 1, 2009; 8(1): 22 - 28. [Abstract] [PDF] E. Kondo, B. Maecker, M. R. Weihrauch, C. Wickenhauser, W. Zeng, L. M. Nadler, J. L. Schultze, and M. S. von Bergwelt-Baildon Cyclin D1-Specific Cytotoxic T Lymphocytes Are Present in the Repertoire of Cancer Patients: Implications for Cancer Immunotherapy Clin. Cancer Res., October 15, 2008; 14(20): 6574 - 6579. [Abstract] [Full Text] [PDF] J. A. Barnett, D. L. Urbauer, G. I. Murray, G. N. Fuller, and A. B. 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