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Prepublished online as a Blood First Edition Paper on July 3, 2003; DOI 10.1182/blood-2003-05-1383. This Article Full Text (PDF) All Versions of this Article: 2003-05-1383v1 102/8/3003    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kienle, D. Articles by Stilgenbauer, S. Search for Related Content PubMed PubMed Citation Articles by Kienle, D. Articles by Stilgenbauer, S. Social Bookmarking                   What's this? Submitted May 2, 2003 Accepted December 31, 1969 VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics, and outcome Dirk Kienle, Alexander Kroeber, Tiemo Katzenberger, German Ott, Elke Leupolt, Thomas F E Barth, Peter Moeller, Axel Benner, Annett Habermann, Hans Konrad Mueller-Hermelink, Martin Bentz, Peter Lichter, Hartmut Doehner, and Stephan Stilgenbauer* Department of Internal Medicine III, University of Ulm, Ulm, Germany Department of Pathology, University of Wuerzburg, Wuerzburg, Germany Department of Pathology, University of Ulm, Ulm, Germany Department of Biostatistics, DKFZ, Heidelberg, Germany Department of Molecular Genetics, DKFZ, Heidelberg, Germany * Corresponding author; email: stephan.stilgenbauer{at}medizin.uni-ulm.de. The immunoglobulin variable heavy chain gene (VH) mutation status and the VDJ rearrangement structure was analyzed in 141 mantle cell lymphoma (MCL) cases and correlated with biological and clinical characteristics. 29% of the MCL displayed mutated VH using a 98% germline homology cut-off. There were striking differences between the VH mutation subgroups with respect to the usage of specific V genes. Rearrangements involving V4-34 and V3-21 were almost exclusively unmutated, whereas rearrangements using V4-59 and V3-23 were typically mutated. There was a significant association of mutated VH with shorter CDR3 lengths and the usage of JH4b. V3-21 and V4-59 were involved in highly characteristic rearrangements implicating that antigen specificity may be involved in MCL development. There was no evidence for isotype switch recombination or Bcl-6 expression in any MCL. ZAP70 expression was not different in VH mutated or unmutated MCL. While the deletions 11q- and 17p- showed a balanced distribution, an overrepresentation was observed for the trisomies +3q, +8q, and tetraploidy in the VH unmutated and +12q in the VH mutated subgroup. Clinically, mutated VH was associated with a higher rate of complete remission, but there was no correlation between VH mutation status and other clinical characteristics or overall survival. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: F. Forconi, E. Sozzi, E. Cencini, F. Zaja, T. Intermesoli, C. Stelitano, L. Rigacci, F. Gherlinzoni, R. Cantaffa, A. Baraldi, et al. Hairy cell leukemias with unmutated IGHV genes define the minor subset refractory to single-agent cladribine and with more aggressive behavior Blood, November 19, 2009; 114(21): 4696 - 4702. [Abstract] [Full Text] [PDF] J. Gao, L. Peterson, B. Nelson, C. Goolsby, and Y.-H. 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S. Dyer, M. J. Terol, D. Pinkel, et al. Mantle-cell lymphoma genotypes identified with CGH to BAC microarrays define a leukemic subgroup of disease and predict patient outcome Blood, June 1, 2005; 105(11): 4445 - 4454. [Abstract] [Full Text] [PDF] R. J. Bende, W. M. Aarts, R. G. Riedl, D. de Jong, S. T. Pals, and C. J.M. van Noesel Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity J. Exp. Med., April 18, 2005; 201(8): 1229 - 1241. [Abstract] [Full Text] [PDF] H. Kohlhammer, C. Schwaenen, S. Wessendorf, K. Holzmann, H. A. Kestler, D. Kienle, T. F. E. Barth, P. Moller, G. Ott, J. Kalla, et al. Genomic DNA-chip hybridization in t(11;14)-positive mantle cell lymphomas shows a high frequency of aberrations and allows a refined characterization of consensus regions Blood, August 1, 2004; 104(3): 795 - 801. [Abstract] [Full Text] [PDF] G. Babbage, R. Garand, N. Robillard, N. Zojer, F. K. Stevenson, and S. S. 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