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Prepublished online as a Blood First Edition Paper on August 21, 2003; DOI 10.1182/blood-2003-05-1401. This Article Full Text (PDF) All Versions of this Article: 2003-05-1401v1 103/1/216    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chim, C.-S. Articles by Kwong, Y.-L. Search for Related Content PubMed PubMed Citation Articles by Chim, C.-S. Articles by Kwong, Y.-L. Social Bookmarking                   What's this? Submitted May 5, 2003 Accepted August 12, 2003 Primary nasal natural killer cell lymphoma: long-term treatment outcome and relationship with the international prognostic index Chor-Sang Chim, Shing-Yan Ma, Wing-Yan Au, Carolyn Choy, Albert K Lie, Raymond Liang, Chun-Chung Yau, and Yok-Lam Kwong* Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong Department of Pathology, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong Department of Radiation Oncology, University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong * Corresponding author; email: ylkwong{at}hkucc.hku.hk. Nasal natural-killer (NK) cell lymphoma is rare, so that its optimal therapy, long-term outcome and prognostic factors are unclear. Fifty-two male and fifteen female patients with well-characterized nasal NK cell lymphomas were analyzed retrospectively to define the impact of primary therapy on remission and long-term outcome, and the validity of the International-Prognostic-Index (IPI). The majority (84%) had stage I/II disease with IPI1 (52%). Seven patients received radiotherapy only; 47 patients received anthracycline-containing chemotherapy plus consolidation radiotherapy; 12 patients received non-anthracycline-containing chemotherapy plus radiotherapy. The overall complete-remission (CR) rate was 64.2%; the 20-year overall-survival (OS) and disease-free-survival (DFS) were 37.1% and 33.5%. Frontline radiotherapy was apparently better than chemotherapy for CR (100% versus 59%, p=0.04) and OS (83.3% versus 32.0%, p=0.03). Relapses occurred in four radiotherapy-treated (all local) and 14 chemotherapy-treated patients (nine local, four systemic). Amongst these, five late relapses (four local, one systemic) occurred at 170 (92-348) months from CR. The IPI score was of prognostic significance for the whole group (IPI1 superior to IPI2 for 20-year OS: 57.4% versus 27.6%, p=0.012), as well as for patients treated with chemotherapy / radiotherapy (IPI1 superior to IPI2 for CR: 76.7% versus 35.7%, p=0.017; and 10-year OS: 63.8% versus 26.8%, p=0.003). CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Z.-Y. Wang, Y.-X. Li, W.-H. Wang, J. Jin, H. Wang, Y.-W. Song, Q.-F. Liu, S.-L. Wang, Y.-P. Liu, S.-N. Qi, et al. Primary radiotherapy showed favorable outcome in treating extranodal nasal-type NK/T-cell lymphoma in children and adolescents Blood, November 26, 2009; 114(23): 4771 - 4776. [Abstract] [Full Text] [PDF] R. Suzuki, J. Suzumiya, M. Yamaguchi, S. Nakamura, J. Kameoka, H. Kojima, M. Abe, T. Kinoshita, T. Yoshino, K. Iwatsuki, et al. 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Clinical heterogeneity of extranodal NK/T-cell lymphoma, nasal type: a national survey of the Korean Cancer Study Group Ann. Onc., August 1, 2008; 19(8): 1477 - 1484. [Abstract] [Full Text] [PDF] K. J. Savage Prognosis and Primary Therapy in Peripheral T-Cell Lymphomas Hematology, January 1, 2008; 2008(1): 280 - 288. [Abstract] [Full Text] [PDF] S. Kim, B. Kim, C. Choi, J Choi, I Kim, Y-H Lee, and J. Kim Ki-67 expression is predictive of prognosis in patients with stage I/II extranodal NK/T-cell lymphoma, nasal type Ann. Onc., August 1, 2007; 18(8): 1382 - 1387. [Abstract] [Full Text] [PDF] C. Bossard, K. Belhadj, F. Reyes, N. Martin-Garcia, F. Berger, J. A. Kummer, J. Briere, A.-C. Baglin, S. Cheze, J. Bosq, et al. 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