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Prepublished online as a Blood First Edition Paper on July 10, 2003; DOI 10.1182/blood-2003-05-1419. This Article Full Text (PDF) All Versions of this Article: 2003-05-1419v1 102/9/3206    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Liu, L. Articles by Broxmeyer, H. E Search for Related Content PubMed PubMed Citation Articles by Liu, L. Articles by Broxmeyer, H. E Social Bookmarking                   What's this? Submitted May 6, 2003 Accepted June 30, 2003 Selective enhancement of multipotential hematopoietic progenitors in vitro and in vivo by IL-20 Ling Liu*, Chunjin Ding, Wei Zeng, Josef G Heuer, Jonathan W Tetreault, Timothy W Noblitt, Giao Hangoc, Scott Cooper, Kellie A Brune, Ganesh Sharma, Niles Fox, Scott W Rowlinson, Danise P Rogers, Derrick R Witcher, Peter K Lambooy, Victor J Wroblewski, James R Miller, and Hal E Broxmeyer Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA Department of Microbiology and Immunology and The Walther Oncology Center, and The Walther Cancer Institute, Indiana University School of Medicine, Indianapolis, IN, USA * Corresponding author; email: liu_ling{at}Lilly.com. In a search for novel growth factors, we discovered that human IL-20 enhanced colony formation by CD34+ multipotential progenitors. IL-20 had no effect on erythroid, granulocyte-macrophage or megakaryocyte progenitors. IL-20 transgenic mice had increased numbers and cell cycling of multipotential, but not other progenitors. IL-20 administration to normal mice significantly increased only multipotential progenitor cells. This demonstrates that IL-20 significantly influences hematopoiesis, with specificity towards multipotential progenitors. This is the first cytokine with such specificity identified. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. Wolk, K. Witte, E. Witte, S. Proesch, G. Schulze-Tanzil, K. Nasilowska, J. Thilo, K. Asadullah, W. Sterry, H.-D. Volk, et al. Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes J. Leukoc. Biol., May 1, 2008; 83(5): 1181 - 1193. [Abstract] [Full Text] [PDF] S. M. Sa, P. A. Valdez, J. Wu, K. Jung, F. Zhong, L. Hall, I. Kasman, J. Winer, Z. Modrusan, D. M. Danilenko, et al. The Effects of IL-20 Subfamily Cytokines on Reconstituted Human Epidermis Suggest Potential Roles in Cutaneous Innate Defense and Pathogenic Adaptive Immunity in Psoriasis J. Immunol., February 15, 2007; 178(4): 2229 - 2240. [Abstract] [Full Text] [PDF] W.-Y. Chen, B.-C. Cheng, M.-J. Jiang, M.-Y. Hsieh, and M.-S. Chang IL-20 Is Expressed in Atherosclerosis Plaques and Promotes Atherosclerosis in Apolipoprotein E-Deficient Mice Arterioscler Thromb Vasc Biol, September 1, 2006; 26(9): 2090 - 2095. [Abstract] [Full Text] [PDF] R. P. Donnelly, F. Sheikh, S. V. Kotenko, and H. Dickensheets The expanded family of class II cytokines that share the IL-10 receptor-2 (IL-10R2) chain J. Leukoc. Biol., August 1, 2004; 76(2): 314 - 321. [Abstract] [Full Text] [PDF] F. Sheikh, V. V. Baurin, A. Lewis-Antes, N. K. Shah, S. V. Smirnov, S. Anantha, H. Dickensheets, L. Dumoutier, J.-C. Renauld, A. Zdanov, et al. Cutting Edge: IL-26 Signals through a Novel Receptor Complex Composed of IL-20 Receptor 1 and IL-10 Receptor 2 J. Immunol., February 15, 2004; 172(4): 2006 - 2010. [Abstract] [Full Text] [PDF]

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