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Prepublished online as a Blood First Edition Paper on July 17, 2003; DOI 10.1182/blood-2003-05-1448. This Article Full Text (PDF) All Versions of this Article: 2003-05-1448v1 102/9/3420    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Taraschi, T. F Articles by Moriyama, Y. Search for Related Content PubMed PubMed Citation Articles by Taraschi, T. F Articles by Moriyama, Y. Social Bookmarking                   What's this? Submitted May 9, 2003 Accepted July 7, 2003 Generation of an erythrocyte vesicle transport system by Plasmodium falciparum malaria parasites Theodore F Taraschi*, Megan O'Donnell, Sandra Martinez, Timothy Schneider, Darin Trelka, Velia M Fowler, Leann Tilley, and Yoshinori Moriyama Department of Pathology, Anatomy & Cell Biology, Thomas Jefferson University, Philadelphia, PA, USA Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, CA, USA Department of Pathology, University of Virginia, Charlottesville, VA, USA Department of Cell Biology, Scripps Research Institute, La Jolla, CA, USA Department of Biochemistry, LaTrobe University, Bundoora, VIC, Australia Department of Biochemistry, Okayama Univesity, Okayama, Japan * Corresponding author; email: Theodore.Taraschi{at}jefferson.edu. The asexual maturation of Plasmodium falciparum is accompanied by the transport of parasite encoded proteins to the erythrocyte plasma membrane. Activation of G-proteins by treatment with aluminum fluoride produced an accumulation within the erythrocyte cytosol of vesicles coated with Plasmodium homologues of COPII and N-ethylmaleimide-sensitive factor, proteins involved in intracellular transport between the Golgi apparatus and the endoplasmic reticulum. These vesicles contain malarial proteins that appear on the erythrocyte plasma membrane, as well as actin and myosin. It is proposed that the parasite adapted a process well established for intracellular transport to mediate the extracellular movement of its proteins through the erythrocyte cytosol to the surface membrane. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. Ayong, A. Raghavan, T. G. Schneider, T. F. Taraschi, D. A. Fidock, and D. Chakrabarti The Longin Domain Regulates the Steady-State Dynamics of Sec22 in Plasmodium falciparum Eukaryot. Cell, September 1, 2009; 8(9): 1330 - 1340. [Abstract] [Full Text] [PDF] M. D. Lazarus, T. G. Schneider, and T. F. Taraschi A new model for hemoglobin ingestion and transport by the human malaria parasite Plasmodium falciparum J. Cell Sci., June 1, 2008; 121(11): 1937 - 1949. [Abstract] [Full Text] [PDF] C. Lavazec, S. Sanyal, and T. J. Templeton Hypervariability within the Rifin, Stevor and Pfmc-2TM superfamilies in Plasmodium falciparum Nucleic Acids Res., December 5, 2006; (2006) gkl942v1. [Abstract] [Full Text] [PDF] C. Spycher, M. Rug, N. Klonis, D. J. P. Ferguson, A. F. Cowman, H.-P. Beck, and L. Tilley Genesis of and Trafficking to the Maurer's Clefts of Plasmodium falciparum-Infected Erythrocytes. Mol. Cell. Biol., June 1, 2006; 26(11): 4074 - 4085. [Abstract] [Full Text] [PDF] S. Frankland, A. Adisa, P. Horrocks, T. F. Taraschi, T. Schneider, S. R. Elliott, S. J. Rogerson, E. Knuepfer, A. F. Cowman, C. I. Newbold, et al. Delivery of the Malaria Virulence Protein PfEMP1 to the Erythrocyte Surface Requires Cholesterol-Rich Domains Eukaryot. Cell, May 1, 2006; 5(5): 849 - 860. [Abstract] [Full Text] [PDF] M. Marti, J. Baum, M. Rug, L. Tilley, and A. F. Cowman Signal-mediated export of proteins from the malaria parasite to the host erythrocyte J. Cell Biol., November 21, 2005; 171(4): 587 - 592. [Abstract] [Full Text] [PDF] E. Knuepfer, M. Rug, N. Klonis, L. Tilley, and A. F. Cowman Trafficking of the major virulence factor to the surface of transfected P falciparum-infected erythrocytes Blood, May 15, 2005; 105(10): 4078 - 4087. [Abstract] [Full Text] [PDF] L. Vincensini, S. Richert, T. Blisnick, A. Van Dorsselaer, E. Leize-Wagner, T. Rabilloud, and C. Braun Breton Proteomic Analysis Identifies Novel Proteins of the Maurer's Clefts, a Secretory Compartment Delivering Plasmodium falciparum Proteins to the Surface of Its Host Cell Mol. Cell. Proteomics, April 1, 2005; 4(4): 582 - 593. [Abstract] [Full Text] [PDF] M. L. Craig, J. N. Waitumbi, and R. P. Taylor Processing of C3b-Opsonized Immune Complexes Bound to Non-Complement Receptor 1 (CR1) Sites on Red Cells: Phagocytosis, Transfer, and Associations with CR1 J. Immunol., March 1, 2005; 174(5): 3059 - 3066. [Abstract] [Full Text] [PDF]

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