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Prepublished online as a Blood First Edition Paper on September 11, 2003; DOI 10.1182/blood-2003-05-1449. This Article Full Text (PDF) All Versions of this Article: 2003-05-1449v1 103/1/363    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Tournilhac, O. Articles by Travade, P. Search for Related Content PubMed PubMed Citation Articles by Tournilhac, O. Articles by Travade, P. Social Bookmarking                   What's this? Submitted May 9, 2003 Accepted August 29, 2003 Impact of frontline fludarabine and cyclophosphamide combined treatment on peripheral blood stem cell mobilization in B-cell chronic lymphocytic leukemia Olivier Tournilhac, Bruno Cazin, Stephane Lepretre, Marine Divine, Karim Maloum, Alain Delmer, Bernard Grosbois, Pierre Feugier, Frederic Maloisel, Florence Villard, Bruno Villemagne, Dominique Bastit, Karim Belhadj, Nabi Azar, Mauricette Michallet, Geraud Manhes, and Philippe Travade* Service d'Hematologie Clinique, Centre Hospitalier Universitaire, Hotel Dieu, Clermont-Ferrand, France Department of Hematology, Centre Hospitalier Regional Universitaire, Hopital Claude Huriez, Lille, France Department of Hematology, Centre Anti-Cancereux Becquerel, Rouen, France Department of Hematology, Hopital Henri Mondor, AP-HP, Creteil, France Department of Hematology, Hopital Pitie-Salpetriere, AP-HP, Paris, France Department of Hematology, Hopital Hotel Dieu, AP-HP, Paris, France Department of Hematology, Centre Hospitalier Universitaire, Rennes, France Department of Hematology, Centre Hospitalier Universitaire Nancy Brabois, Nancy, France Department of Hematology, Centre Hospitalier Regional Universitaire, Hopital Civil, Strasbourg, Strasbourg, France Department of Hematology, Hopital Edouard Herriot, Lyon, France Departement d'Information Medicale, Centre Hospitalier, Vichy, France * Corresponding author; email: ptravade{at}chu-clermontferrand.fr. Ongoing studies in B-cell chronic lymphocytic leukemia are evaluating autologous peripheral blood stem cell (PBSC) transplantation in first remission following fludarabine. However, fludarabine could impair PBSC harvest. In 38 patients after frontline oral fludarabine and cyclophosphamide (FDR-CY), we prospectively evaluated steady state filgrastim or lenograstim primed PBSC mobilization to collect 2.0 x 106/kg CD34. The first mobilization, done a median of 178 days (range, 69-377)from last FDR-CY course, was unsuccessful in 32 patients. This result was significantly associated with a low platelet count prior to mobilization, but neither with age, interval from last FDR-CY course, initial stage, remission status, nor with other blood parameters. Finally, after 1, 2, and 3 mobilizations in 27, 10, and 1 patients, only 12 had 2.0 x 106/kg CD34 collected. Explorations of the mechanism of poor mobilization and adaptation of PBSC harvest policies following fludarabine treatment are therefore warranted. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Gill, D. Carney, D. Ritchie, M. Wolf, D. Westerman, H. M. Prince, H. Januszewicz, and J. F. Seymour The frequency, manifestations, and duration of prolonged cytopenias after first-line fludarabine combination chemotherapy Ann. Onc., July 22, 2009; (2009) mdp297v1. [Abstract] [Full Text] [PDF] S. Montoto, C. Moreno, E. Domingo-Domenech, C. Estany, A. Oriol, A. Altes, J. Besalduch, C. Pedro, S. Gardella, L. Escoda, et al. High clinical and molecular response rates with fludarabine, cyclophosphamide and mitoxantrone in previously untreated patients with advanced stage follicular lymphoma Haematologica, February 1, 2008; 93(2): 207 - 214. [Abstract] [Full Text] [PDF] M. Kalaycio, L. Rybicki, B. Pohlman, R. Sobecks, S. Andresen, E. Kuczkowski, and B. Bolwell Risk Factors Before Autologous Stem-Cell Transplantation for Lymphoma Predict for Secondary Myelodysplasia and Acute Myelogenous Leukemia J. Clin. Oncol., August 1, 2006; 24(22): 3604 - 3610. [Abstract] [Full Text] [PDF] B. L. Abbott Chronic Lymphocytic Leukemia: Recent Advances in Diagnosis and Treatment Oncologist, January 1, 2006; 11(1): 21 - 30. [Abstract] [Full Text] [PDF] D. W. Milligan, S. Fernandes, R. Dasgupta, F. E. Davies, E. Matutes, C. D. Fegan, C. McConkey, J. A. Child, D. Cunningham, G. J. Morgan, et al. Results of the MRC pilot study show autografting for younger patients with chronic lymphocytic leukemia is safe and achieves a high percentage of molecular responses Blood, January 1, 2005; 105(1): 397 - 404. [Abstract] [Full Text] [PDF]

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