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Blood, 1 February 2004, Vol. 103, No. 3, pp. 963-965.
Prepublished online as a Blood First Edition Paper on October 30, 2003; DOI 10.1182/blood-2003-05-1502.
Submitted May 12, 2003
Accepted September 8, 2003
The variable number of tandem repeat polymorphism of platelet glycoprotein Ib and risk of coronary heart disease
Vahid Afshar-Kharghan, Nevenka Matijevic-Aleksic, Chul Ahn, Eric Boerwinkle, Kenneth K Wu, and Jose A Lopez*
Department of Medicine, Thrombosis Research Section, Baylor College of Medicine, Houston, TX, USA
Department of Medicine and School of Public Health, University of Texas Houston Health Science Center, Houston, TX, USA
* Corresponding author; email: josel{at}bcm.tmc.edu.
Glycoprotein (GP) Ib-IX-V complex plays an important role in formation of platelet-fibrin clot at the area of damaged vessel wall. One polymorphism of GP Ib , the main component of the GP Ib-IX-V complex, is due to variable numbers of tandem repeats in the macroglycopeptide region. We studied the association between the presence of different VNTR alleles of GP Ib and the frequency of coronary heart disease among individuals recruited to a large community-based case-cohort study (Atherosclerosis Risk in Communities or ARIC study). We found that the distribution of VNTR alleles of GP Ib is different among Caucasians and African-Americans. The B allele (with 3 VNTR repeats) of GP Ib is relatively more common among African-Americans compared to Caucasians. In African-Americans, the CC genotype (homozygous with 2 VNTR repeats) is associated with a lower risk of CHD events than all other genotypes.
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