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Blood, 15 June 2004, Vol. 103, No. 12, pp. 4681-4684. Prepublished online as a Blood First Edition Paper on January 22, 2004; DOI 10.1182/blood-2003-05-1548. This Article Full Text (PDF) All Versions of this Article: 2003-05-1548v1 103/12/4681    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ertault-Daneshpouy, M. Articles by Janin, A. Search for Related Content PubMed PubMed Citation Articles by Ertault-Daneshpouy, M. Articles by Janin, A. Social Bookmarking                   What's this? Submitted May 19, 2003 Accepted January 9, 2004 Pericapillary hemorrhage as criterion of severe human digestive graft-versus-host disease Marjan Ertault-Daneshpouy, Christophe Leboeuf, Marc Lemann, Fatiha Bouhidel, Lionel Ades, Eliane Gluckman, Gerard Socie, and Anne Janin* IFR105, INSERM ERM 0220 et Universite Paris VII, Paris, France; Service de Pathologie, INSERM ERM 0220 et Universite Paris VII, Paris, France IFR105, INSERM ERM 0220 et Universite Paris VII, Paris, France Service hepato-gastro-enterologie, AP-HP, Hopital Saint Louis, Paris, France Service d'Hematologie Greffe de Moelle, AP-HP, Hopital Saint Louis, Paris, France IFR105, INSERM ERM 0220 et Universite Paris VII, Paris, France; Service d'Hematologie Greffe de Moelle, AP-HP, Hopital Saint Louis, Paris, France * Corresponding author; email: anne_janin{at}yahoo.com. In an experimental model we demonstrated that endothelial cells of all organs are targets of the alloimmune reaction. Here, in 68 digestive biopsies, we found endothelial lesions by immunohistochemistry and ultrastructure in patients with severe acute graft-versus-host disease (GVHD). In contrast, no such endothelial cell alterations were found either in patients without GVHD or in non-grafted controls. In the biopsies with severe GVHD lesions, ultrastructure showed rupture of the capillary basal membrane and extravased red blood cells. These pericapillary hemorrhages were highly correlated with GVHD severity. In a separate cohort of 39 patients who underwent an allogeneic transplantation after a non-myeloablative conditioning, 8 patients had intestinal biopsies. Three of these later patients had both severe pathological lesions of GVHD and similar endothelial lesions, thus, strengthening the concept that endothelial lesions are linked to GVHD severity and not to the intensity of the conditioning regimen. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Murata, A. Janin, C. Leboeuf, J. Soulier, E. Gluckman, V. Meignin, and G. Socie Donor-derived cells and human graft-versus-host disease of the skin Blood, March 15, 2007; 109(6): 2663 - 2665. [Abstract] [Full Text] [PDF] M. Kummer, A. Lev, Y. Reiter, and B. C. Biedermann Vascular Endothelial Cells Have Impaired Capacity to Present Immunodominant, Antigenic Peptides: A Mechanism of Cell Type-Specific Immune Escape J. Immunol., February 15, 2005; 174(4): 1947 - 1953. [Abstract] [Full Text] [PDF]

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