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Prepublished online as a Blood First Edition Paper on September 25, 2003; DOI 10.1182/blood-2003-05-1557. This Article Full Text (PDF) All Versions of this Article: 2003-05-1557v1 103/3/843    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Osborn, M. J Articles by Tudor, K.-S. R S Search for Related Content PubMed PubMed Citation Articles by Osborn, M. J Articles by Tudor, K.-S. R S Social Bookmarking                   What's this? Submitted May 15, 2003 Accepted September 15, 2003 Overexpression of murine TSLP impairs lymphopoiesis and myelopoiesis Mark J Osborn, Patricia L Ryan, Nicole Kirchhof, Angela Panoskaltsis-Mortari, Frank Mortari, and Kim-Sue R S Tudor* Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA Veterinary Diagnostic Laboratory, University of Minnesota, Minneapolis, MN, USA Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA Cancer Center Histopathology Core, University of Minnesota, Minneapolis, MN, USA R & D Systems Inc., Minneapolis, MN, USA * Corresponding author; email: tudor004{at}umn.edu. The role of Thymic Stromal Cell-derived Lymphopoietin (TSLP) in regulating hematopoiesis is poorly characterized; therefore, we investigated its regulatory effects in vivo utilizing TSLP transgenic mice. Over-expression of TSLP disrupted hematopoietic homeostasis by causing imbalances in lymphopoiesis and myelopoiesis. Mice harboring a TSLP transgene had 5-700-fold fewer B and T precursors and no detectable pre-B lymphocyte colony forming activity in the marrow or spleen. Conversely, TSLP transgenic mice possessed 15-20 times more splenic myeloid precursors than their littermates, and CFU-GEMM progenitor activity was significantly elevated. The arrest in lymphopoiesis and the expansion of myeloid progenitor cells in TSLP-transgenic mice suggest that TSLP has negative and positive regulatory effects on lymphoid and myeloid development, respectively. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Chappaz, L. Flueck, A. G. Farr, A. G. Rolink, and D. Finke Increased TSLP availability restores T- and B-cell compartments in adult IL-7 deficient mice Blood, December 1, 2007; 110(12): 3862 - 3870. [Abstract] [Full Text] [PDF] B. Terrier, M. Ittah, L. Tourneur, F. Louache, V. Soumelis, F. Lavie, N. Casadevall, S. Candon, A. Hummel, X. Mariette, et al. Late-onset neutropenia following rituximab results from a hematopoietic lineage competition due to an excessive BAFF-induced B-cell recovery Haematologica, February 1, 2007; 92(2): e20 - e23. [Abstract] [Full Text] [PDF] J. Yoo, M. Omori, D. Gyarmati, B. Zhou, T. Aye, A. Brewer, M. R. Comeau, D. J. Campbell, and S. F. Ziegler Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin J. Exp. Med., August 15, 2005; 202(4): 541 - 549. [Abstract] [Full Text] [PDF] A. Al-Shami, R. Spolski, J. Kelly, T. Fry, P. L. Schwartzberg, A. Pandey, C. L. Mackall, and W. J. Leonard A Role for Thymic Stromal Lymphopoietin in CD4+ T Cell Development J. Exp. Med., July 19, 2004; 200(2): 159 - 168. [Abstract] [Full Text] [PDF] C. A. Goetz, I. R. Harmon, J. J. O'Neil, M. A. Burchill, and M. A. Farrar STAT5 Activation Underlies IL7 Receptor-Dependent B Cell Development J. Immunol., April 15, 2004; 172(8): 4770 - 4778. [Abstract] [Full Text] [PDF]

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