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Blood, 1 March 2004, Vol. 103, No. 5, pp. 1580-1585. Prepublished online as a Blood First Edition Paper on November 6, 2003; DOI 10.1182/blood-2003-05-1595. This Article Full Text (PDF) All Versions of this Article: 2003-05-1595v1 103/5/1580    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Papayannopoulou, T. Search for Related Content PubMed PubMed Citation Articles by Papayannopoulou, T. Social Bookmarking                   What's this? Submitted May 20, 2003 Accepted October 29, 2003 Current mechanistic scenarios in hemopoietic stem/progenitor cell mobilization Thalia Papayannopoulou* Department of Medicine, Division of Hematology, University of Washington, Seattle, WA, USA * Corresponding author; email: thalp{at}u.washington.edu. Uncovering the molecular mechanisms governing the exit of stem/progenitor cells from bone marrow to peripheral blood at steady-state or after their enforced migration has been an ongoing challenge. Recently, however, several new avenues or paradigms in mobilization have emerged from ever-expanding work in humans subjected to G-CSF mobilization, as well as from studies in normal and gene-deficient mouse models. Although these developments represent notable advances that met with considerable excitement, they have been quenched by surprising vacillations in subsequent research. This perspective highlights recent developments in mobilization along with their controversies. A full understanding of the directional cues that control the migratory behavior and the fate of stem/progenitor cells once they migrate out of bone marrow will await further experimentation, aiming to bridge our current gaps in knowledge. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Ross and L. Li HSC mobilization: new incites and insights Blood, August 13, 2009; 114(7): 1283 - 1284. [Full Text] [PDF] M. J. Christopher, F. Liu, M. J. Hilton, F. Long, and D. C. Link Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization Blood, August 13, 2009; 114(7): 1331 - 1339. [Abstract] [Full Text] [PDF] M. S. Goligorsky This extraordinary extramedullary haematopoiesis Nephrol. Dial. Transplant., July 1, 2009; 24(7): 2016 - 2017. [Full Text] [PDF] Y. Tan, Y. Li, J. Xiao, H. Shao, C. Ding, G. E. Arteel, K. A. Webster, J. Yan, H. Yu, L. 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